Reproductive and anthropometric factors in relation to the risk of lobular and ductal breast carcinoma among women 65-79 years of age
Reproductive and anthropometric factors in relation to the risk of lobular and ductal breast carcinoma among women 65-79 years of age
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DOI：
10.1002/ijc.11465
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发表时间：
2003-11-20
影响因子：
6.4
通讯作者：
Daling, JR
中科院分区：
文献类型：
--
作者：
Li, CI;Malone, KE;Daling, JR
联合使用雌激素-孕酮激素替代疗法似乎与浸润性小叶乳腺癌（ILC）的风险增加相关，在较小程度上，与浸润性导管癌（IDC）的风险相关。可以想象，ILC对生殖反应更敏感，因此可能比IDCs更强烈地与生殖和人体测量特征相关，这些特征可以影响激素水平。然而，很少有乳腺癌的流行病学研究评估这些因素的组织学类型。我们对华盛顿州西部65-79岁的妇女进行了一项基于人群的病例对照研究。在1997 - 1999年期间，975名被诊断患有乳腺癌的妇女的反应与1,007名对照者的反应进行了比较。使用多分类logistic回归评估各种生殖和人体测量因素与IDC（n = 656）和ILC（n = 196）风险之间的关联。与ILC相比，初潮年龄早、绝经年龄晚和肥胖与IDC风险升高的相关性更强。或者，口服避孕药的使用与ILC的风险增加有关，但与IDC无关。因此，我们观察到的结果模式表明，影响内源性激素和卵巢功能持续时间的因素可能与IDC风险更密切相关，而外源性激素可能与ILC风险更密切相关。(C)2003 Wiley-Liss，Inc.
Use of combined estrogen-progestin hormone replacement therapy appears to be associated with an increased risk of invasive lobular breast carcinomas (ILC) and, to a lesser degree, with risk of invasive ductal carcinoma (IDC). Conceivably, ILCs are more hormonally responsive and so may be more strongly associated than IDCs with reproductive and anthropometric characteristics that can influence hormone levels. However, few epidemiologic studies of breast cancer have evaluated these factors by histologic type. We conducted a population-based case-control study of women aged 65-79 years in western Washington State. Responses from 975 women diagnosed with breast cancer during 19971999 were compared to those of 1,007 controls. Associations between various reproductive and anthropometric factors and risks of IDC (n = 656) and ILC (n = 196) were evaluated using polytomous logistic regression. Earlier age at menarche, later age at menopause and obesity were more strongly associated with elevated risks of IDC than ILC. Alternatively, oral contraceptive use was associated with an increased risk of ILC but not IDC. Thus, the pattern of results that we observed suggest that factors influencing endogenous hormones and duration of ovarian function may be more strongly associated with IDC risk, while exogenous hormones may be more strongly associated with ILC risk. (C) 2003 Wiley-Liss, Inc.