Quantitative approaches to analyzing imatinib-treated chronic myeloid leukemia
Quantitative approaches to analyzing imatinib-treated chronic myeloid leukemia
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DOI：
10.1016/j.tips.2007.03.003
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发表时间：
2007-05-01
影响因子：
13.8
通讯作者：
Michor, Franziska
中科院分区：
文献类型：
--
作者：
Michor, Franziska
Progress in understanding the genetic changes that drive tumorigenesis has enabled the development of molecularly targeted anticancer therapy. The first small molecule targeted to a specific protein was imatinib mesylate (Gleevec, ST1571), which is used to treat chronic myeloid leukemia (CML). A recent article presents a computational model with which to study the treatment response in CML patients and investigates the effect that imatinib exerts on leukemic stem cells. Here, I discuss insights derived from this study and their implications for imatinib therapy against CML.
