Measurement of gastric emptying and gastric motility by magnetic resonance imaging (MRI)
Measurement of gastric emptying and gastric motility by magnetic resonance imaging (MRI)
复制标题
通过磁共振成像 (MRI) 测量胃排空和胃动力
DOI：
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发表时间：
1994
影响因子：
3.1
通讯作者：
M. Fried
中科院分区：
文献类型：
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作者：
W. Schwizer;W. Schwizer;Robert J. Fraser;Robert J. Fraser;J. Borovicka;J. Borovicka;G. Crelier;G. Crelier;Peter Boesiger;Peter Boesiger;M. Fried;M. Fried
到目前为止，还不可能无创地测量人类胃的多个区域的胃排空和运动。我们描述了一种利用磁共振成像(MRI)来实现这一点的新方法的发展。在5名健康志愿者身上进行的初步验证研究显示，摄入标记有[Gd]DOTA的10%葡萄糖后，胃排空曲线和分泌率相似，通过MRI([Gd]DOTA作为膳食标记)和同步双指示器技术进行评估。对5名患者进行核磁共振成像和核素扫描的比较也得出了类似的结果。应用较新的MRI技术，允许一系列相隔1.2秒的冠状扫描，可以量化7名健康志愿者近端和远端胃的壁运动。这些结果表明，MRI为正常和紊乱排空的机制提供了新的见解。
Hitherto it has been impossible to measure noninvasively gastric emptying and motility from multiple regions of the stomach in humans. We describe the development of a novel methodology to achieve this using magnetic resonance imaging (MRI). Initial validation studies performed in five healthy volunteers demonstrated similar gastric emptying curves and secretion rates after ingestion of 10% dextrose labeled with [Gd]DOTA, assessed by MRI ([Gd]DOTA as meal marker) and a simultaneous double-indicator technique. Comparison between MRI and scintigraphy in five patients also gave similar results. Application of newer MRI technology allowing a series of coronal scans 1.2 sec apart permitted quantification of wall motion in the proximal and distal stomach in seven healthy volunteers. These results indicate that MRI provides new insights into the mechanisms responsible for both normal and disordered emptying.