Comparison of the efficacy between topical diquafosol and artificial tears in the treatment of dry eye following cataract surgery: A meta-analysis of randomized controlled trials.
Comparison of the efficacy between topical diquafosol and artificial tears in the treatment of dry eye following cataract surgery: A meta-analysis of randomized controlled trials.
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DOI：
10.1097/md.0000000000008174
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发表时间：
2017-09
期刊：
影响因子：
1.6
通讯作者：
Chen Y
中科院分区：
文献类型：
--
作者：
Zhao X;Xia S;Chen Y
据报道，白内障手术后干眼的患病率高达55.7%，这一急性和医源性疾病迫切需要临床治疗。本研究的目的是比较地喹磷钠眼液(DQS)和传统人工泪液(AT)治疗白内障术后干眼的疗效。从最早的条目到2017年6月，搜索了PubMed、Embase和Cochrane Central Register of Control Trials，以获得这些研究，这些研究评估了DQS对白内障手术后干眼患者的疗效。相关数据用StataSE 12.0软件进行统计分析。采用PRISMA量表作为Meta分析的方案，并遵循指南。加权平均差值、相对危险度及其95%可信区间被用来评估这种关联的强度。作者鉴定了21篇文献，其中包括4篇评价DQS对白内障术后干眼患者疗效的研究。数据集包括291例白内障术后干眼患者(371只眼)。本研究的综合结果显示，在角膜和结膜荧光素染色评分、泪膜破裂时间、泪液分泌试验等指标上，丹参散组明显优于AT(P <； .05)。虽然症状问卷评分不能统一，但各研究的结果也证明DQS能更好地缓解术后干眼症状。根据现有证据，外用DQS治疗白内障手术后干眼的疗效优于AT；但需要进行更大样本量的进一步研究，并将重点放在高阶像差、症状问卷评分和成本-效果比等指标上，才能得出更确切的结论。
The prevalence of dry eye following cataract surgery was reported as high as 55.7%, this acute and iatrogenic disorder urgently required appropriate clinical management. The purpose of this study is to compare the efficacy of diquafosol sodium ophthalmic solution (DQS) and conventional artificial tears (AT) for the treatment of dry eye following cataract surgery. The PubMed, Embase, and the Cochrane Central Register of Controlled Trials were searched from their earliest entries through June 2017 to obtain the studies, which evaluated the efficacy of DQS for patients with dry eye after cataract surgery. The relevant data were analyzed using StataSE 12.0 software. The PRISMA checklist was used as protocol of the meta-analysis and the guideline was followed. The weighted mean difference, relative risk, and their 95% confidence interval were used to assess the strength of the association. The authors identified 21 references of which 4 studies evaluating the efficacy of DQS for patients with dry eye after cataract surgery were included. The dataset consisted of 291 patients of dry eye following cataract surgery (371 postoperative eyes). The pooling result of our study suggested that the DQS could significantly better improve the indices like corneal and conjunctival fluorescein staining scores, tear breakup time, and Schirmer I test than AT (P < .05). Although the scores of symptom questionnaire could not be pooled, the results of each study also proved that DQS could significantly better relieve the symptoms of postoperative dry eye. Based on the available evidence, topical DQS has a superior efficacy than AT in the management of dry eye after cataract surgery; however, further researches with larger sample sizes and focus on indicators such as higher-order aberrations, symptom questionnaire scores, and cost-effective ratio are required to reach a firmer conclusion.