GnRH-PAP hormonotoxin targets cytotoxicity to prostate cancer cell lines.
GnRH-PAP hormonotoxin targets cytotoxicity to prostate cancer cell lines.
复制标题
GnRH-PAP 激素毒素针对前列腺癌细胞系的细胞毒性。
DOI：
10.1007/s00240-003-0352-z
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发表时间：
2003
影响因子：
--
通讯作者：
Glode,LMichael
中科院分区：
文献类型：
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作者：
Qi,Lin;Nett,TerryM;Allen,MatthewC;Sha,Xiaoming;Harrison,GailS;Frederick,BarbaraA;Glode,LMichael
美洲商陆抗病毒蛋白（PAP）是一种植物来源的高效核糖体失活蛋白，可抑制蛋白质翻译并导致细胞快速死亡。我们先前已经描述了GnRH（促性腺激素释放激素）受体靶向结合蛋白（GnRH-PAP）的强效细胞毒性活性，并证明细胞毒性取决于GnRH受体的数量和暴露的持续时间。在这里，我们证明了GnRH-PAP偶联物对三种不同的前列腺癌细胞系具有细胞毒性，支持使用这种激素毒素作为治疗前列腺癌等前列腺癌反应性癌症的新疗法的可行性。
Pokeweed antiviral protein (PAP) is a plant-derived, highly potent ribosome inactivating protein that causes inhibition of protein translation and rapid cell death. We have previously described potent cytotoxic activity of a GnRH (gonadotropin-releasing hormone) receptor-targeted conjugate protein (GnRH-PAP) and demonstrated that cytotoxicity depended on the number of GnRH receptors and the duration of exposure. Here, we demonstrate that the GnRH-PAP conjugate was cytotoxic to three different prostate cancer cell lines, supporting the feasibility of using such hormonotoxins as novel therapeutics for hormone-responsive cancers such as prostate cancer.