NanoDDS'06. Proceedings of the 4th International Nanomedicine and Drug Delivery Symposium, October 8-10, 2006, Omaha, Nebraska, USA.
NanoDDS'06. Proceedings of the 4th International Nanomedicine and Drug Delivery Symposium, October 8-10, 2006, Omaha, Nebraska, USA.
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纳米DDS06。
DOI：
10.1016/j.jconrel.2007.05.035
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发表时间：
2007
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本期《控制释放杂志》提供了第四届国际纳米药物和药物释放研讨会(NanoDDS‘06：www.纳诺兹。Org/)于2007年10月8日至10日在美国内布拉斯加州奥马哈举行[1]。这次研讨会的重点是纳米医学的最新进展，特别是用于诊断和治疗人类疾病的纳米系统。2006年专题讨论会延续了2003年在内布拉斯加州奥马哈举行的美日小型联合专题讨论会发起的一系列会议，随后于2004年在纽约布鲁克林举行了第二次专题讨论会[2、3]，并于2005年在马里兰州巴尔的摩举行了第三次专题讨论会[4]。第四届研讨会吸引了来自16个国家的近180名科学家，24名知名专家作为嘉宾演讲，数十名海报主持人。为纪念已故教授维克托·A·卡巴诺夫(Victor A.Kabanov，1934-2006)，日本东京大学的片冈和则(Kazunori Kataoka)教授是首批研讨会系列组织者之一。受邀讲座的主题包括纳米材料化学和工程、纳米颗粒在细胞中的命运和功能、用于癌症治疗的纳米药物、用于生物成像的纳米技术方法、神经退行性疾病的病理学和治疗以及病原体检测。一个由学术和工业科学家组成的小组批判性地讨论了新型纳米药物临床开发中的挑战。这一问题提出了2006年研讨会期间讨论的一些重要主题。特别关注用于药物和基因输送的新型纳米材料的设计和评价。其中一篇文章讨论了用创新的光刻技术制备聚合物纳米颗粒。另一篇文章提供了用于将核苷类似物输送到细胞中的可生物降解纳米凝胶载体的配方的最新进展。读者非常感兴趣的将是一篇讨论微粒形状作为微米和纳米药物输送载体的重要设计参数的文章。一些出版物提出了基因传递的主题，包括开发用于基因传递的新型胶体稳定的共聚体系，以及使用多细胞肿瘤球体来筛选具有低细胞毒性和高转染率的非病毒聚合基因载体。开发用于分析DNA纳米颗粒细胞内行为的创新方法也引起了相当大的关注，例如荧光相关光谱。总之，我们相信本期杂志的许多读者将感兴趣，并将很好地补充最近的另外两期特刊，介绍本系列以前的研讨会的原创和评论投稿[3，4]。
This issue of the Journal of Controlled Release offers several publications from participants of the Fourth International Nanomedicine and Drug Delivery Symposium (NanoDDS’06: www. nanodds. org/) held on October 8–10, 2007 in Omaha, Nebraska, USA [1]. This symposium focused on recent advances in nanomedicine, especially nanosystems for diagnosis and therapy of human diseases. The 2006 symposium continued a series of meetings initiated as a joint US/Japan Mini-Symposium in 2003 in Omaha, Nebraska and followed by the second symposium in 2004 in Brooklyn, New York [2, 3] and the third symposium in 2005 in Baltimore, Maryland [4]. The fourth symposium attracted nearly 180 scientists from 16 countries, 24 leading experts as guest speakers and several dozen poster presenters. One of the initial symposium series organizers, Prof. Kazunori Kataoka of University of Tokyo, Japan presented a Plenary Lecture in honor and memory of late Professor Victor A. Kabanov (1934-2006). The topics of invited lectures covered nanomaterial chemistry and engineering, fate and function of nanoparticles in cells, nanomedicines for cancer therapy, nanotechnology approaches for bioimaging, pathology and therapy of neurodegenerative disorders and pathogen detection. A panel of leading academic and industrial scientists critically discussed challenges in clinical development of novel nanomedicines.This issue presents some important topics that were covered during the 2006 symposium. Particular attention is in design and evaluation of novel nanomaterials for drug and gene delivery. One of the articles discusses fabrication of polymeric nanoparticles by innovative lithographic technique. Another article provides an update on formulations of biodegradable nanogel carriers for delivery of nucleoside analogs into a cell. Of significant interest to the readers will be an article discussing particle shape as an important design parameter for microand nanoscale drug delivery carriers. A theme of gene delivery is presented by several publications including development of novel colloidally stable copolymer systems for gene delivery and use of multicellular tumor spheroids for screening non-viral polymeric gene vectors with low cytotoxicity and high transfection efficiencies. Considerable attention is also in development of innovative approaches for analysis of the intracellular behavior of DNA nanoparticles such as fluorescence correlation spectroscopy. All together, we believe that this issue will be of interest to numerous readers of the journal and will nicely supplement two other recent special issues presenting original and review contributions from the previous symposia of this series [3, 4].