Bioavailability of PCDDs and PCDFs on fly ash after semi-chronic oral ingestion by guinea pig and syrian golden hamster
Bioavailability of PCDDs and PCDFs on fly ash after semi-chronic oral ingestion by guinea pig and syrian golden hamster
复制标题
豚鼠和叙利亚金仓鼠半慢性口服后飞灰上 PCDDs 和 PCDFs 的生物利用度
DOI：
10.1016/0045-6535(86)90546-1
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发表时间：
1986
期刊：
影响因子：
8.8
通讯作者：
O. Hutzinger
中科院分区：
文献类型：
--
作者：
M. Berg;E. D. Vroom;K. Olie;O. Hutzinger
豚鼠和叙利亚金黄地鼠组分别在一个，两个和三个月期间，在饮食中喂食2.5%盐酸预处理的飞灰从静电除尘器的城市焚化炉。对肝脏进行了四氯、五氯和六氯二苯并（p）二恶英（PCDDs）和二苯并呋喃（PCDFs）分析。在仓鼠的肝脏中，2，3，7，8-取代的多氯二苯并对二恶英和多氯二苯并呋喃是主要的异构体。在豚鼠的肝脏中，保留了2，3，7，8取代的多氯二苯并对二恶英和多氯二苯并呋喃同系物，但也保留了一些其他取代的多氯二苯并呋喃。在豚鼠肝脏中保留最高的PCDF同系物是1，2，3，7，8-PnCDF，95天后保留率为11.3%。在仓鼠的肝脏中，发现2，3，4，7，8-PnCDF的保留最高，95天后为8.4%。对于大多数2，3，7，8-取代的多氯二苯并对二恶英和多氯二苯并呋喃而言，在整个期间豚鼠和仓鼠肝脏中的滞留量没有显著差异，这可能表明生物浓缩与给药剂量接近线性关系。在这三个时间段内，两个物种的肝脏中2，3，7，8-取代的五氯和六氯多氯二苯并对二恶英和多氯二苯并呋喃的相对浓度恒定。
Groups of guinea pigs and syrian golden hamster were fed 2.5% HCl pre-treated fly ash from the electrostatic precipitator of a municipal incinerator during one, two, and three months, respectively, in the diet. The livers were analyzed for tetra-, penta-, and hexa-chlorinated dibenzo(p)dioxines (PCDDs) and dibenzofurans (PCDFs). In the livers of the hamsters 2,3,7,8-substituted PCDDs and PCDFs were the major isomers retained. In the livers of the guinea pigs 2,3,7,8 substituted PCDDs and PCDF congeners were retained, but also a number of otherwise substituted PCDFs. The PCDF congener which had the highest retention in the livers of guinea pigs was 1,2,3,7,8-PnCDF, 11.3% after 95 days. In the livers of the hamsters highest retention was found for 2,3,4,7,8-PnCDF, 8.4% after 95 days. For most 2,3,7,8-substituted PCDDs and PCDFs the retention in the livers of the guinea pigs and hamsters was not significantly different during the whole period, which could indicate a bioconcentration approaching a linear relationship to the administered dose. Constant relative concentrations in the livers were found for the 2,3,7,8-substituted penta- and hexa-chlorinated PCDDs and PCDF in both species during the three time periods.