Oxidative stress in female cancers.
Oxidative stress in female cancers.
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DOI：
10.18632/oncotarget.25323
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发表时间：
2018-05-04
期刊：
影响因子：
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通讯作者：
Aguayo F
中科院分区：
文献类型：
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作者：
Calaf GM;Urzua U;Termini L;Aguayo F
乳腺癌、宫颈癌和卵巢癌在全世界妇女中非常普遍。环境、激素和病毒相关因素与这些肿瘤的发展尤其相关。这些因素通过产生活性氧（ROS）与氧化应激（OS）密切相关。OS是由生物体氧化还原状态的不平衡引起的，字面上定义为“ROS产生与生物系统对其解毒之间的不平衡，导致细胞/组织损伤修复受损”。肿瘤的多步骤进展表明OS参与了肿瘤的发生、发展和进展。本文就OS在乳腺癌、宫颈癌和卵巢癌发生、发展中的作用及其与环境、宿主和病毒因素的相互作用进行综述。此外，天然抗氧化剂化合物姜黄素和其他化合物对乳腺癌，宫颈癌和卵巢癌预防/治疗的作用进行了讨论。
Breast, cervical and ovarian cancers are highly prevalent in women worldwide. Environmental, hormonal and viral-related factors are especially relevant in the development of these tumors. These factors are strongly related to oxidative stress (OS) through the generation of reactive oxygen species (ROS). The OS is caused by an imbalance in the redox status of the organism and is literally defined as “an imbalance between ROS generation and its detoxification by biological system leading to impairment of damage repair by cell/tissue”. The multistep progression of cancer suggests that OS is involved in cancer initiation, promotion and progression. In this review, we described the role of OS and the interplay with environmental, host and viral factors related to breast, cervical and ovarian cancers initiation, promotion and progression. In addition, the role of the natural antioxidant compound curcumin and other compounds for breast, cervical and ovarian cancers prevention/treatment is discussed.