SARS-CoV-2 T cell immunity: Specificity, function, durability, and role in protection
SARS-CoV-2 T cell immunity: Specificity, function, durability, and role in protection
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DOI：
10.1126/sciimmunol.abd6160
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发表时间：
2020-07-01
影响因子：
24.8
通讯作者：
Boyton, Rosemary J.
中科院分区：
文献类型：
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作者：
Altmann, Daniel M.;Boyton, Rosemary J.
为了综合清楚地了解SARS-CoV-2(严重急性呼吸综合征冠状病毒2号)的保护性免疫，抗体分析与无症状、轻度和严重新冠肺炎(冠状病毒病2019)的T细胞研究平行进行。考虑到抗体反应似乎是短暂的，T细胞记忆可能更持久，确定CD4和CD8效应器在保护中的功能是重要的。为了充分了解人群水平的免疫，使用标准化的检测方法对抗体和T细胞免疫进行筛查将是有益的。
In efforts to synthesize a clear understanding of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) protective immunity, antibody analysis has been paralleled by T cell studies across asymptomatic, mild, and severe COVID-19 (coronavirus disease 2019). Defining CD4 and CD8 effector functions in protection is important, considering that antibody responses appear short-lived and T cell memory is potentially more durable. To fully understand population-level immunity, screening for both antibody and T cell immunity using standardized testing methods would be beneficial.