Clinical and histopathological features of NASH in workers exposed to chemicals with or without associated metabolic conditions
Clinical and histopathological features of NASH in workers exposed to chemicals with or without associated metabolic conditions
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DOI：
10.1111/j.1478-3231.2004.0897.x
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发表时间：
2004-04-01
影响因子：
6.7
通讯作者：
Andrade, Z
中科院分区：
文献类型：
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作者：
Cotrim, HP;De Freitas, LA;Andrade, Z
背景/目标：非酒精性脂肪性肝炎（NASH）与巴西一家工业综合体的工人接触化学品有关。我们研究了这些与代谢状况相关或无关的个体的NASH特征。研究方法：84名NASH患者被分为三组：G1，31名暴露于化学品（苯、二甲苯、氯乙烯等）的患者; G2，30名暴露于化学品（苯、二甲苯、氯乙烯等）的患者，这些患者还表现出肥胖、高脂血症和糖尿病; G3，23名未暴露于化学品（苯、二甲苯、氯乙烯等）的患者，这些患者表现出代谢疾病。结果：G1和G2在性别（97%和100%男性）和年龄（37+/-5.4和39+/-6.5岁）方面相似。在G3中，74%为男性，年龄为48 ± 3.4岁（P
Background/Aims: Non-alcoholic steatohepatitis (NASH) has been associated with exposure to chemicals among workers from an industrial complex in Brazil. We investigated the NASH profile of these individuals associated or not with metabolic conditions. Methods: Eighty-four patients with NASH were classified into three groups: G1, 31 patients exposed to chemicals (benzene, xylene, vinyl chloride and others); G2, 30 exposed patients who also presented with obesity, hyperlipidemia and diabetes; and G3, 23 non-exposed patients who presented with metabolic conditions. Results: G1 and G2 were similar in terms of gender (97% and 100% males) and age (37+/-5.4 and 39+/-6.5 years). In G3, 74% were males and the age was 48+/-3.4 years (P