Five-Year Survey (2014 to 2018) of Azole Resistance in Environmental Aspergillus fumigatus Isolates from China
Five-Year Survey (2014 to 2018) of Azole Resistance in Environmental Aspergillus fumigatus Isolates from China
复制标题
中国环境烟曲霉唑类耐药性五年调查（2014-2018）
DOI：
10.1128/aac.00904-20
复制
发表时间：
2020-10-01
影响因子：
4.9
通讯作者：
Yu, Yunlong
中科院分区：
文献类型：
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作者：
Cao, Duantao;Wu, Ruilin;Yu, Yunlong
共提交了来自中国杭州的191个土壤样品，以检测非野生型（非WT）烟曲霉及其相关机制。2014年、2016年和2018年分别有2（4.7%）、13（12.4%）和31（23.1%）株分离株被鉴定为非WT。在3、5和5株非WT分离株中发现了TR 34/L98 H、TR 46/Y121 F/T289 A和TR 34/L98 H/S297 T/F495 I耐药突变。G448 S突变，以前只在临床上发现，在A。土壤样本中的烟曲霉。摘要本研究对杭州市191个土壤样品进行了非野生型烟曲霉菌的检测，并探讨了烟曲霉菌的致病机理。2014年、2016年和2018年分别有2（4.7%）、13（12.4%）和31（23.1%）株分离株被鉴定为非WT。在3、5和5株非WT分离株中发现了TR 34/L98 H、TR 46/Y121 F/T289 A和TR 34/L98 H/S297 T/F495 I耐药突变。G448 S突变，以前只在临床上发现，在A。土壤样本中的烟曲霉。
A total of 191 soil samples from Hangzhou, China, were submitted to detect non-wild-type (non-WT) Aspergillus fumigatus and its associated mechanisms. There were 2 (4.7%), 13 (12.4%), and 31 (23.1%) isolates identified as non-WT in 2014, 2016, and 2018, respectively. The resistant mutations of TR34/L98H, TR46/Y121F/T289A, and TR34/L98H/S297T/F495I were found in 3, 5, and 5 non-WT isolates. The G448S mutation, previously only found in clinical settings, was detected in A. fumigatus from soil samples. ABSTRACT A total of 191 soil samples from Hangzhou, China, were submitted to detect non-wild-type (non-WT) Aspergillus fumigatus and its associated mechanisms. There were 2 (4.7%), 13 (12.4%), and 31 (23.1%) isolates identified as non-WT in 2014, 2016, and 2018, respectively. The resistant mutations of TR34/L98H, TR46/Y121F/T289A, and TR34/L98H/S297T/F495I were found in 3, 5, and 5 non-WT isolates. The G448S mutation, previously only found in clinical settings, was detected in A. fumigatus from soil samples.