Tunable Nanopore Arrays as the Basis for Ionic Circuits
Tunable Nanopore Arrays as the Basis for Ionic Circuits
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DOI：
10.1021/acsami.0c18574
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发表时间：
2020-12-16
影响因子：
9.5
通讯作者：
Siwy, Zuzanna S.
中科院分区：
文献类型：
--
作者：
Lucas, Rachel A.;Siwy, Zuzanna S.
制备能够操纵溶液中的离子和分子输运的离子电路已经引起了相当大的兴趣。这一研究方向的灵感来自于生物系统，其中嵌入细胞膜中的具有不同功能的多个孔传递外部信号并构成所有生理过程的基础。在这篇手稿中，我们描述了通过由3个，6个和9个纳米孔组成的纳米孔的小阵列和放置在膜表面上的一个孔开口旁边的集成栅电极的离子传输的建模。我们表明，通过调整栅极电压和战略性地放置具有非线性电流-电压特性的纳米孔，在栅极的局部信号影响离子通过阵列中的所有纳米孔的传输。当相同的栅极电压引起相邻纳米孔相反的整流特性时，确定了条件。我们还表明，嵌入在纳米孔阵列中的离子二极管可以调制相邻孔的传输特性，即使没有栅极电压。浓差极化的作用和重叠的耗尽区一侧的膜上的结果进行了解释。这里提出的建模旨在成为未来实验的灵感，以创建可以在空间和时间中识别信号的纳米孔阵列。
There has been considerable interest in preparing ionic circuits capable of manipulating ionic and molecular transport in a solution. This direction of research is inspired by biological systems where multiple pores with different functionalities embedded in a cell membrane transmit external signals and underlie all physiological processes. In this manuscript, we describe the modeling of ion transport through small arrays of nanopores consisting of 3, 6, and 9 nanopores and an integrated gate electrode placed on the membrane surface next to one pore opening. We show that by tuning the gate voltage and strategically placing nanopores with nonlinear current-voltage characteristics, the local signal at the gate affects ionic transport through all nanopores in the array. Conditions were identified when the same gate voltage induced opposite rectification properties of neighboring nanopores. We also demonstrate that an ionic diode embedded in a nanopore array can modulate transport properties of neighboring pores even without a gate voltage. The results are explained by the role of concentration polarization and overlapping depletion zones on one side of the membrane. The modeling presented here is intended to become an inspiration to future experiments to create nanopore arrays that can transduce signals in space and time.