Effects of inhaled steroids on growth, bone metabolism and adrenal function.
Effects of inhaled steroids on growth, bone metabolism and adrenal function.
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DOI：
10.1586/17476348.1.1.65
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发表时间：
2007-08-01
影响因子：
3.9
通讯作者：
Allen, David B
中科院分区：
文献类型：
--
作者：
Allen, David B
吸入性糖皮质激素是治疗儿童持续性哮喘的一线药物。长期吸入皮质类固醇治疗的主要安全性问题包括抑制肾上腺功能、生长和骨发育。正确解释吸入性皮质类固醇安全性研究需要了解各种吸入性皮质类固醇药物/给药装置系统之间的差异。剂量、使用的吸入器装置类型、患者技术和个体药物的特征影响吸入皮质类固醇的全身效应。当严重哮喘需要持续高剂量治疗或处方剂量过大且依从性异常良好时，可能会发生全身副作用。然而，总体而言，最近的研究证实，正确处方和使用吸入性皮质类固醇的益处不仅明显超过其潜在的不良反应，而且还超过与哮喘控制不良相关的风险。
Inhaled corticosteroids are a first-line therapy for persistent asthma in children. Major safety concerns of long-term inhaled corticosteroid therapy include suppression of adrenal function, growth and bone development. Proper interpretation of inhaled corticosteroid safety studies requires knowledge of the differences among various inhaled corticosteroid drug/delivery device systems. Dosage, type of inhaler device used, patient technique and characteristics of the individual drug influence the systemic effects of inhaled corticosteroids. Systemic side effects can occur when continuous high-dose treatment is required for severe asthma or when the dosage prescribed is excessive and compliance unusually good. Overall, however, recent studies confirm that benefits of inhaled corticosteroids, properly prescribed and used, clearly outweigh not only their potential adverse effects, but also the risks associated with poorly controlled asthma.