Epithelial dysplasia of the rabbit colon induced by degraded carrageenan.
Epithelial dysplasia of the rabbit colon induced by degraded carrageenan.
复制标题
降解角叉菜胶诱导兔结肠上皮发育不良。
作者：
A. Kitano;T. Matsumoto;M. Hiki;H. Hashimura;K. Yoshiyasu;K. Okawa;S. Kuwajima;K. Kobayashi
根据我们的方法，通过短期（7至8周）给予角叉菜胶，可以在兔中诱导结肠粘膜病变，其特征在于隐窝膨胀和单核细胞浸润，类似于人溃疡性结肠炎。在这项研究中，实验性结肠上皮发育不良是由p.o.施用葡聚糖降解的角叉菜胶更长的时间。15只家兔，致敏i.m. 1周前用相同物质处理的小鼠，用1%角叉菜胶的饮用水溶液处理12或28个月。组织学检查显示，所有动物的结肠粘膜主要为轻度炎性变化，治疗28个月的5只动物中有3只出现局灶性但高度异型增生（非息肉样），涉及粘膜上皮。目前的观察结果表明，结肠上皮异型增生可能与炎症有关，我们产生的病理条件可以是一个有用的模型，原位癌可能导致炎症。
Colonic mucosal lesions, characterized by crypt abscesses and mononuclear cell infiltration, which resemble human ulcerative colitis can be induced in rabbits by short-term (7 to 8 weeks) administration of carrageenan according to our method. In this study experimental epithelial dysplasia of the colon was induced by the p.o. administration of lambda-degraded carrageenan for a much longer period of time. Fifteen rabbits, sensitized i.m. with the same substance 1 week before, were subjected to 12 or 28 months of treatment with 1% carrageenan solution in drinking water. Histological examination disclosed chiefly mild inflammatory changes of the colonic mucosa in all animals and a focal but high-grade dysplasia (nonpolypoid) involving the mucosal epithelium in three of the five animals treated for 28 months. The present observations suggested that epithelial dysplasia of the colon may be caused in association with inflammation and that the pathological condition produced by us can be a useful model of carcinoma in situ possibly resulting from inflammation.