Potential Therapeutic Effects of Egg Yolk Antibody (IgY) in Helicobacter pylori Infections─A Review.
Potential Therapeutic Effects of Egg Yolk Antibody (IgY) in Helicobacter pylori Infections─A Review.
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DOI：
10.1021/acs.jafc.1c05398
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发表时间：
2021-11
影响因子：
6.1
通讯作者：
Leheng Zhang;Yire Xiao;Linhua Ji;Min-Zen Lin;Yikui Zou;Jingjing Zhao;Suqing Zhao
中科院分区：
文献类型：
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作者：
Leheng Zhang;Yire Xiao;Linhua Ji;Min-Zen Lin;Yikui Zou;Jingjing Zhao;Suqing Zhao
目前，幽门螺杆菌感染影响着世界上大约一半的人口，而治疗幽门螺杆菌感染的最常用的方法是：幽门螺杆菌的一线治疗是基于克拉霉素的三联疗法或四联疗法。然而，H.幽门螺杆菌感染对全球卫生保健界构成严重挑战。因此，新的治疗H.幽门螺杆菌感染是迫切需要的。鸡蛋黄作为免疫球蛋白Y（IgY）的来源，因其提取成本低、对动物的伤害和痛苦最小、无特异性耐药性等优点而引起人们的关注，因此被认为是H.幽门感染本文对H.幽门螺杆菌抗原制备IgY的应用，机制和局限性。
Currently, the infection with Helicobacter pylori affects about half of the world's population, and the most common therapy to treat H. pylori is the first line clarithromycin-based triple therapy or the quadruple therapy. However, drug resistance, eradication in a low level, high rate of reinfection, and gastrointestinal side effects among the causative organisms for H. pylori infection pose a critical challenge to the global health care community. Therefore, new approaches to treat H. pylori infections are urgently needed. Chicken egg yolk constituting a source of immunoglobulin Y (IgY) has attracted noticeable attention for its advantages of cost-effective extraction, minimization of animal harm and suffering, and induction of no specific resistance and is, therefore, being regarded as an alternative therapy for H. pylori infection. This review is intended to summarize various H. pylori antigens for IgY preparation in terms of their application, mechanism, and limitations.