EFFECTS OF METHYLDOPA ON UTEROPLACENTAL AND FETAL HEMODYNAMICS IN PREGNANCY-INDUCED HYPERTENSION
EFFECTS OF METHYLDOPA ON UTEROPLACENTAL AND FETAL HEMODYNAMICS IN PREGNANCY-INDUCED HYPERTENSION
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DOI：
10.1016/s0002-9378(12)90905-9
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发表时间：
1993-01-01
影响因子：
9.8
通讯作者：
RATNAM, SS
中科院分区：
文献类型：
--
作者：
MONTAN, S;ANANDAKUMAR, C;RATNAM, SS
目的：我们的目的是研究甲基多巴对子宫胎盘和胎儿血流动力学的影响，在妇女与妊娠高血压综合征研究设计：多普勒超声血流数据的前瞻性研究之前和之后1周的甲基多巴治疗进行了妇产科，国立大学医院，新加坡，在20名妇女（平均35周的妊娠）与妊娠高血压综合征。主要结果指标为母体血压、母体和胎儿心率以及以胎儿升主动脉、大脑中动脉、脐动脉和母体子宫动脉和弓状动脉搏动指数为特征的血流速度波形。结果：产妇平均动脉压降低9.7 mm Hg（95%可信区间-13.8 ~-5.6），平均心率降低6.3次/min（95%可信区间-11.1 ~-1.4）。治疗后子宫动脉（0.93 - 0.92）和弓状动脉（0.61 - 0.73）的平均脉动指数无变化。治疗前后胎儿血流动力学变化不明显。胎儿和新生儿的结果是uneventure.CONCLUSION：短期治疗与甲基多巴在妊娠高血压综合征的妇女在最后三个月降低产妇的血压和心率，但对子宫胎盘和胎儿的血流动力学没有不良影响。
OBJECTIVE: Our purpose was to study the effect of methyldopa on uteroplacental and fetal hemodynamics in women with pregnancy-induced hypertension.STUDY DESIGN: A prospective study of Doppler ultrasonographic blood flow data before and after 1 week of methyldopa treatment was conducted at the Department of Obstetrics and Gynecology, National University Hospital, Singapore, in 20 women (mean 35 weeks' gestation) with pregnancy-induced hypertension. The main outcome measures were maternal blood pressure, maternal and fetal heart rate, and blood velocity waveforms characterized by the pulsatility index in the fetal ascending aorta, middle cerebral artery, umbilical artery, and maternal uterine and arcuate arteries. Statistical evaluation was performed with t tests for paired observations.RESULTS: Maternal mean arterial blood pressure was reduced 9.7 mm Hg (95% confidence interval -13.8 to -5.6), and mean heart rate decreased 6.3 beats/min (95% confidence interval -11.1 to -1.4). Mean pulsatility index in the uterine (0.93 to 0.92) and arcuate arteries (0.61 to 0.73) were unchanged after treatment. Fetal hemodynamic changes before and after treatment were not significant. Fetal and neonatal outcome was uneventful.CONCLUSION: Short-term treatment with methyldopa in the last trimester in women with pregnancy-induced hypertension reduced maternal blood pressure and heart rate but had no adverse effects on uteroplacental and fetal hemodynamics.