The interaction between radiation and adriamycin damage in mammalian cells.
The interaction between radiation and adriamycin damage in mammalian cells.
复制标题
哺乳动物细胞中辐射和阿霉素损伤之间的相互作用。
作者：
J. Belli;A. Piro
辐射和阿霉素损伤之间的相互作用降低了X射线生存曲线的肩部宽度。发现这种作用在阿霉素处理后持续至少24小时。当细胞在两次剂量分割前或在X射线照射之间接受阿霉素治疗时，阿霉素不影响辐射损伤。阿霉素的独特之处在于其对辐射反应的主要作用是降低存活曲线肩，而不影响两次剂量恢复。有人建议，阿霉素和辐射产生独立的类别的损害，表示相互杀死，关于登记的亚致死辐射损伤，但后者的修复是不受阿霉素。
Interaction between radiation and Adriamycin damage reduced the width of the shoulder of the X-ray survival curve. This effect was found to persist for at least 24 hr after Adriamycin treatment. Adriamycin did not affect radiation damage when cells were treated either before two-dose fractionation or with the drug present between X-ray exposures. Adriamycin is unique in that its major effect on radiation response is to reduce the survival curve shoulder without affecting two-dose recovery. It is suggested that Adriamycin and radiation produce independent classes of damage that are expressed mutually for killing, with regard to the registration of sublethal radiation damage, but that repair of the latter is unaffected by Adriamycin.