Paramagnetic Properties of Metal-Free Boron-Doped Graphene Quantum Dots and Their Application for Safe Magnetic Resonance Imaging.
Paramagnetic Properties of Metal-Free Boron-Doped Graphene Quantum Dots and Their Application for Safe Magnetic Resonance Imaging.
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DOI：
10.1002/adma.201605416
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发表时间：
2017-03
期刊：
影响因子：
--
通讯作者：
Zhang M
中科院分区：
文献类型：
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作者：
Wang H;Revia R;Wang K;Kant RJ;Mu Q;Gai Z;Hong K;Zhang M
该研究介绍了硼掺杂石墨烯量子点（B-GQD）作为安全MRI和荧光成像的无金属多模态造影剂（CA）。体内T1加权MR图像显示，B-GQDs在心、肝、脾和肾上引起显著的对比增强，并且持续超过1小时，比目前临床上使用的Gd基CA长约10倍。
The study introduces a boron-doped graphene quantum dot (B-GQD) as a metal-free multi-modal contrast agent (CA) for safe MRI and fluorescence imaging. In vivo T1-weighted MR images shows B-GQDs induce significant contrast enhancement on heart, liver, spleen and kidney and sustain for more than 1 h, about 10 times longer than Gd-based CAs currently used in clinic.