EFFECTS OF CHRONIC DENERVATION IN TYPE-I CUTANEOUS MECHANORECEPTORS (HAARSCHEIBEN)
EFFECTS OF CHRONIC DENERVATION IN TYPE-I CUTANEOUS MECHANORECEPTORS (HAARSCHEIBEN)
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DOI：
10.1002/ar.1092070109
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发表时间：
1983-01-01
影响因子：
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通讯作者：
HORCH, K
中科院分区：
文献类型：
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作者：
ENGLISH, KB;KAVKAVANNORMAN, D;HORCH, K
皮肤I型受体网站（Haarscheiben或触觉圆顶）进行了检查，在4至275天的时间间隔后，慢性皮肤去神经支配。圆顶的数量随着去神经时间的推移而减少，并且在275天时只有约1/3的最初存在的圆顶仍然可见。大多数，但不是所有的默克尔细胞从这些圆顶缺席48天，上皮显着薄于非去神经支配的圆顶。只有少数被检查的圆顶似乎完全没有默克尔细胞。神经切断后，圆顶退化，但并不总是完全消失。残余物可以作为靶位点，其吸引再生的I型神经纤维或促进神经再生后新的圆顶结构的形成。
Cutaneous type I receptor sites (Haarscheiben or tactile domes) were examined at intervals of 4 to 275 days after chronic denervation of the skin. The number of domes decreased with denervation time, and only about 1/3 of the domes originally present were still visible at 275 days. Most but not all of the Merkel cells from these domes were absent by 48 days, and the epithelium was significantly thinner than in nondenervated domes. Only a few of the examined domes appeared to be completely devoid of Merkel cells. After nerve transection, domes degenerate but do not always disappear entirely. The remnants may act as target sites which either attract regenerating type I nerve fibers or facilitate the formation of new dome structures after nerve regeneration.