SECRETION, PAIN AND SNEEZING INDUCED BY THE APPLICATION OF CAPSAICIN TO THE NASAL-MUCOSA IN MAN
SECRETION, PAIN AND SNEEZING INDUCED BY THE APPLICATION OF CAPSAICIN TO THE NASAL-MUCOSA IN MAN
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DOI：
10.1111/j.1476-5381.1988.tb10305.x
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发表时间：
1988-03-01
影响因子：
7.3
通讯作者：
SICUTERI, F
中科院分区：
文献类型：
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作者：
GEPPETTI, P;FUSCO, BM;SICUTERI, F
1 将辣椒素局部涂抹在人的鼻粘膜上会引起烧灼感和打喷嚏。还观察到剂量依赖性鼻浆粘液分泌。辣椒素（75μg）在产生鼻分泌物方面比乙酰胆碱（50mg）更有效，而局部组胺（200μg）、P物质（135μg）和降钙素基因相关肽（36μg）不会引起鼻漏。 2 局部用异丙托溴铵、全身用右氯苯那敏或吲哚美辛进行预处理不会影响辣椒素引起的作用。利多卡因局部预处理可抑制疼痛感，但无法阻止鼻漏。连续使用 4-5 次后，辣椒素的作用就会脱敏，并在 30-40 天内观察到完全恢复。 3 有人提出，辣椒素对人鼻粘膜的作用是由于初级传出神经元的兴奋，这些传出神经元（a）传达灼烧感和疼痛感，（b）引起打喷嚏反射，（c）通过从其外周末端释放递质来诱导鼻分泌。
1 Topical application of capsaicin to the human nasal mucosa induced a burning sensation and sneezing. A dose-dependent seromucous nasal secretion was also observed. Capsaicin (75 .mu.g) was more potent than methacoline (50 mg) in producing nasal secretion, while topical histamine (200 .mu.g), substance P (135 .mu.g) and calcitonin gene-related peptide (36 .mu.g) did not induce rhinorrhea. 2 Pretreatment with either topical ipratropium bromide, systemic dexachlorpheniramine or indomethacin did not influence the effects induced by capsaicin. Topical pretreatment with lidocaine inhibited the painful sensation but failed to block the rhinorrhea. Desensitization to the effects of capsaicin occurred following 4-5 subsequent applications, and full recovery was observed within 30-40 days. 3 It is proposed that the effects of capsaicin in human nasal mucosa are due to excitation of primary efferent neurones that (a) convey burning and painful sensation, (b) evoke a sneezing reflex and (c) induce nasal secretion by releasing transmitter(s) from their peripheral terminals.