Near-infrared study of fluctuations in cerebral hemodynamics during rest and motor stimulation: Temporal analysis and spatial mapping
Near-infrared study of fluctuations in cerebral hemodynamics during rest and motor stimulation: Temporal analysis and spatial mapping
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DOI：
10.1118/1.598943
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发表时间：
2000-04-01
期刊：
影响因子：
3.8
通讯作者：
Gratton, E
中科院分区：
文献类型：
--
作者：
Toronov, V;Franceschini, MA;Gratton, E
我们已经非侵入性地研究了运动皮质血流动力学在人类受试者休息和运动刺激条件下使用多通道近红外组织光谱仪。我们的仪器在两个波长（758和830 nm）下测量大脑皮层的光学地图，每张地图的采集时间为160 ms。我们获得了光学地图的氧合和脱氧血红蛋白浓度变化的折叠平均，功率谱和相干性的振幅在刺激重复频率，和相位同步指数。在周期性运动刺激条件下，我们观察到的相干性和频率或相位同步的局部血流动力学变化与刺激。我们的主要发现如下：（1）运动刺激的血流动力学反应的幅度与静息时的波动幅度相当。(2)氧合血红蛋白和脱氧血红蛋白对刺激的反应的空间模式是不同的。(3)对刺激的血流动力学反应显示出空间定位和与运动刺激的相位同步水平，其取决于刺激周期。(C)2000年美国医学物理学家协会。
We have noninvasively studied the motor cortex hemodynamics in human subjects under rest and motor stimulation conditions using a multichannel near-infrared tissue spectrometer. Our instrument measures optical maps of the cerebral cortex at two wavelengths (758 and 830 nm), with an acquisition time of 160 ms per map. We obtained optical maps of oxy- and deoxy-hemoglobin concentration changes in terms of amplitudes of folding average, power spectrum and coherence at the stimulation repetition frequency, and the phase synchronization index. Under periodic motor stimulation conditions, we observed coherence and frequency or phase synchronization of the local hemodynamic changes with stimulation. Our main findings are the following: (1) The amplitude of the hemodynamic response to the motor stimulation is comparable to the amplitude of the fluctuations at rest. (2) The spatial patterns of the oxy- and deoxy-hemoglobin responses to the stimulation are different. (3) The hemodynamic response to stimulation shows a spatial localization and a level of phase synchronization with the motor stimulation that depends on the stimulation period. (C) 2000 American Association of Physicists in Medicine.