Quantification of respiration-induced abdominal tumor motion and its impact on IMRT dose distributions
Quantification of respiration-induced abdominal tumor motion and its impact on IMRT dose distributions
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DOI：
10.1016/j.ijrobp.2003.09.077
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发表时间：
2004-04-01
影响因子：
7
通讯作者：
Willett, CG
中科院分区：
文献类型：
--
作者：
Gierga, DP;Chen, GTY;Willett, CG
目的：用调强放射治疗移动靶可能会引入剂量输送误差。在腹部的肿瘤的运动进行了研究，使用定量荧光分析，剂量输送到目标的效果studied.Methods和Materials：7例胰腺或肝脏肿瘤和基准剪辑的荧光镜会话记录，转换为数字格式，并进行分析，以量化肿瘤运动的特点。调强放射治疗计划产生的3例（共5个计划），和剂量-体积直方图的目标体积进行了比较计划与无肿瘤motion.Results：峰-峰运动的平均幅度为7例患者在颅尾和AP方向分别为7.4 mm和3.8 mm。钛夹运动变化很大，因为每例患者的最大钛夹偏移比平均钛夹偏移大约47%。列入肿瘤运动并没有导致一个显着的退化，在目标剂量体积直方图为五个治疗plannesstudied.Conclusion：在这项研究中，大多数患者的肿瘤运动量并不大，但在某些情况下，显着降低计划的目标剂量体积直方图。因此，对于某些患者，可能需要在治疗期间进行运动缓解或干预。(C)2004年爱思唯尔公司
Purpose: The treatment of moving targets with intensity-modulated radiotherapy may introduce errors in dose delivery. The motion of tumors in the abdomen was studied using quantitative fluoroscopic analysis, and the effect on dose delivery to the target was studied.Methods and Materials: Fluoroscopy sessions for 7 patients with pancreas or liver tumors and fiducial clips were recorded, converted to digital format, and analyzed to quantify the characteristics of tumor motion. Intensity-modulated radiotherapy plans were generated for 3 patients (a total of five plans), and the dose-volume histograms for the target volume were compared between plans with and without tumor motion.Results: The average magnitude of the peak-to-peak motion for the 7 patients in the craniocaudal and AP directions was 7.4 mm and 3.8 mm, respectively. The clip motion varied widely, because the maximal clip excursions were about 47% greater than the average clip excursions for each patient. The inclusion of tumor motion did not lead to a significant degradation in the target dose-volume histogram for four of five treatment plans studied.Conclusion: The amount of tumor motion for most patients in this study was not large but could, in some instances, significantly degrade the planned target dose-volume histogram. For some patients, therefore, motion mitigation or intervention during treatment may be necessary. (C) 2004 Elsevier Inc.