Distinctive expression of myelomonocytic markers and down‐regulation of CD34 in acute myelogenous leukaemia with FLT3 tandem duplication and nucleophosmin mutation
Distinctive expression of myelomonocytic markers and down‐regulation of CD34 in acute myelogenous leukaemia with FLT3 tandem duplication and nucleophosmin mutation
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DOI：
10.1111/j.1600-0609.2007.00866.x
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发表时间：
2007-07
影响因子：
3.1
通讯作者：
Y. Mori;G. Yoshimoto;T. Kumano;T. Miyamoto;T. Iino;K. Takenaka;H. Iwasaki;N. Harada;N. Kinukawa;K. Nagafuji;T. Teshima;K. Shimoda;K. Akashi;M. Harada
中科院分区：
文献类型：
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作者：
Y. Mori;G. Yoshimoto;T. Kumano;T. Miyamoto;T. Iino;K. Takenaka;H. Iwasaki;N. Harada;N. Kinukawa;K. Nagafuji;T. Teshima;K. Shimoda;K. Akashi;M. Harada
目的：急性髓系白血病(AML)患者存在频繁的Flt3基因内部串联重复(Flt3-ITD)和核磷蛋白突变(NPM1-mt)。在此背景下，我们研究了Flt3-ITD和/或NPM1-mt的生物学和临床意义。
Objective: Patients with acute myelogenous leukaemia (AML) show co‐existing frequently internal tandem duplications of FLT3 (FLT3‐ITD) and mutations of nucleophosmin (NPM1‐Mt). We investigated the biological and clinical significance of FLT3‐ITD and/or NPM1‐Mt in this context.