Intertwined regulation between RNA m(6)A modification and cancer metabolism.
Intertwined regulation between RNA m(6)A modification and cancer metabolism.
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DOI：
10.1016/j.cellin.2022.100075
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发表时间：
2023-02
期刊：
影响因子：
--
通讯作者：
Liu, Hudan
中科院分区：
文献类型：
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作者：
Liu, Jiaxu;Huang, Hao;Zhang, Minghao;Qing, Guoliang;Liu, Hudan
RNA N6-甲基腺苷（m6 A）是RNA转录物中最常见、最丰富和最保守的内部修饰，尤其是在真核生物信使RNA（mRNAs）中。越来越多的证据表明，RNA m6 A修饰利用广泛的调控机制来控制包括癌症在内的病理生理过程中的基因表达。代谢重编程已被广泛认为是癌症的标志。癌细胞通过多种内源性和外源性信号通路获得代谢适应，促进细胞在营养供应有限的微环境中生长和存活。最近出现的证据揭示了癌细胞中m6 A修饰和代谢紊乱事件之间的相互调节，增加了代谢重新布线的细胞网络的复杂性。本文就RNA甲基化对肿瘤代谢的影响以及代谢中间产物对m6 A修饰的反馈调控作一综述。我们的目的是强调RNA m6 A修饰和癌症代谢之间的重要联系，并期望RNA m6 A和代谢重编程的研究将导致对癌症病理学的更深入的了解。
RNA N6-methyladenosine (m6A) has been identified as the most common, abundant and conserved internal modification in RNA transcripts, especially within eukaryotic messenger RNAs (mRNAs). Accumulating evidence demonstrates that RNA m6A modification exploits a wide range of regulatory mechanisms to control gene expression in pathophysiological processes including cancer. Metabolic reprogramming has been widely recognized as a hallmark of cancer. Cancer cells obtain metabolic adaptation through a variety of endogenous and exogenous signaling pathways to promote cell growth and survival in the microenvironment with limited nutrient supply. Recent emerging evidence reveals reciprocal regulation between the m6A modification and disordered metabolic events in cancer cells, adding more complexity in the cellular network of metabolic rewiring. In this review, we summarize the most recent advances of how RNA methylation affects tumor metabolism and the feedback regulation of m6A modification by metabolic intermediates. We aim to highlight the important connection between RNA m6A modification and cancer metabolism, and expect that studise of RNA m6A and metabolic reprogramming will lead to greater understanding of cancer pathology.