THE IMPACT OF LONG-TERM WARFARIN THERAPY ON QUALITY-OF-LIFE - EVIDENCE FROM A RANDOMIZED TRIAL
THE IMPACT OF LONG-TERM WARFARIN THERAPY ON QUALITY-OF-LIFE - EVIDENCE FROM A RANDOMIZED TRIAL
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DOI：
10.1001/archinte.151.10.1944
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发表时间：
1991-10-01
影响因子：
--
通讯作者：
KISTLER, JP
中科院分区：
文献类型：
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作者：
LANCASTER, TR;SINGER, DE;KISTLER, JP
为了确定长期接受华法林钠治疗对生活质量的影响，我们调查了333名参与华法林预防非风湿性心房颤动卒中的随机对照试验的患者。在华法林治疗的患者和对照组患者之间，在功能状态、幸福感和健康感知的良好验证测量上没有发现显著差异。例如，华法林治疗组的健康认知总分为68.8分，而对照组为66.6分(范围从0到100；差异的95%可信区间为-1.6到6.0)。相比之下，服用华法林并有出血事件的患者的健康感知显著下降(-11.9；95%可信区间-4.1至-91.6)。华法林治疗通常不会显著降低患者的健康水平，除非发生了出血事件。华法林治疗对健康认知的负面影响可以通过对其保护作用的信心来平衡。
To determine the effect of long-term warfarin sodium therapy on quality of life, we surveyed 333 patients participating in a randomized, controlled trial of warfarin for the prevention of stroke in nonrheumatic atrial fibrillation. No significant differences between warfarin-treated and control patients were found on well-validated measures of functional status, well-being, and health perceptions. For example, the summary score for health perceptions was 68.8 in the warfarin-treated vs 66.6 in the control group (scale of 0 to 100; 95% confidence intervals for the difference, -1.6 to 6.0). In contrast, patients taking warfarin who had a bleeding episode had a significant decrease in health perceptions (-11.9; 95% confidence interval, -4.1 to -91.6). Warfarin therapy is not usually associated with a significant decrease in perceived health, unless a bleeding episode has occurred. Negative effects of warfarin treatment on health perceptions may be balanced by confidence in its protective effects.