Expansion of the Family of Molecular Nanoparticles of Cerium Dioxide and Their Catalytic Scavenging of Hydroxyl Radicals
Expansion of the Family of Molecular Nanoparticles of Cerium Dioxide and Their Catalytic Scavenging of Hydroxyl Radicals
复制标题
二氧化铈分子纳米颗粒家族的扩展及其对羟基自由基的催化清除
DOI：
10.1021/acs.inorgchem.0c03133
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发表时间：
2021
影响因子：
4.6
通讯作者：
Christou, George
中科院分区：
文献类型：
--
作者：
Mitchell, Kylie J.;Goodsell, Justin L.;Russell-Webster, Bradley;Twahir, Umar T.;Angerhofer, Alexander;Abboud, Khalil A.;Christou, George
合成，晶体结构，和催化自由基清除活性的报告，从自下而上的分子方法，以纳米CeO 2的四个新的分子簇。它们是[Ce 6 O 4（OH）4（dmb）12（H2O）4]（dmb-= 2，6-二甲氧基苯甲酸酯）、[Ce 16 O 17（OH）6（O2 CPh）24（HO 2CPh）4]、[Ce 19 O 18（OH）9（O2 CPh）27（H2O）（py）3]和[Ce 24 O27（OH）9（O2 CPh）30（py）4]。它们代表了我们所谓的这种金属氧化物的“分子纳米颗粒”家族的一个主要扩展，其晶体结构证实了它们的核心都具有大块CeO 2的萤石结构。此外，它们还允许识别表面特征，如多个Ce 3+离子的接近位置和以前未见过的有机配体结合模式。所有七个成员的能力，以催化氧化活性氧物种进行了研究，使用HO·自由基，一个重要的测试反应，在二氧化铈纳米粒子生物医学文献中，大多数已被发现表现出优异的抗氧化活性相比，传统的二氧化铈纳米粒子，其活性与其表面Ce 3+含量成反比。
The syntheses, crystal structures, and catalytic radical scavenging activity are reported for four new molecular clusters that have resulted from a bottom-up molecular approach to nanoscale CeO2. They are [Ce6O4(OH)4(dmb)12(H2O)4] (dmb–= 2,6-dimethoxybenzoate), [Ce16O17(OH)6(O2CPh)24(HO2CPh)4], [Ce19O18(OH)9(O2CPh)27(H2O)(py)3], and [Ce24O27(OH)9(O2CPh)30(py)4]. They represent a major expansion of our family of so-called “molecular nanoparticles” of this metal oxide to seven members, and their crystal structures confirm that their cores all possess the fluorite structure of bulk CeO2. In addition, they have allowed the identification of surface features such as the close location of multiple Ce3+ions and organic ligand binding modes not seen previously. The ability of all seven members to catalytically scavenge reactive oxygen species has been investigated using HO•radicals, an important test reaction in the ceria nanoparticle biomedical literature, and most have been found to exhibit excellent antioxidant activities compared to traditional ceria nanoparticles, with their activity correlating inversely with their surface Ce3+content.