A novel antigenic variant of Canine parvovirus from a Vietnamese dog
A novel antigenic variant of Canine parvovirus from a Vietnamese dog
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DOI：
10.1007/s00705-004-0367-y
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发表时间：
2004-11-01
影响因子：
2.7
通讯作者：
Akashi, H
中科院分区：
文献类型：
--
作者：
Nakamura, M;Tohya, Y;Akashi, H
从越南犬、猫体内分离到9株犬细小病毒(CPV)。其中一株犬分离株表现出独特的抗原性，当用我们最近研制的单抗21C3和19D7进行血凝抑制试验时，表明这是CPV-2b的一个新的抗原性变体。该分离株的氨基酸序列由426位天冬氨酸替换为谷氨酸，最近在意大利犬的CPV中也发现了相同的氨基酸替换。这项研究首次表明，这种替换导致了由单抗证明的抗原性差异，越南的CPV可能也发生了类似的进化。
Nine isolates of Canine parvovirus (CPV) were obtained from Vietnamese dogs and cats. One canine isolate showed a unique antigenic property which indicates a novel antigenic variant of CPV-2b when examined with hemagglutination inhibition tests using our monoclonal antibodies, 21C3 and 19D7, which were recently developed. This isolate had an amino acid substitution of residue 426, Asp to Glu, and the same substitution has recently been found in CPV from Italian dogs. This study first showed that such substitution caused an antigenic difference demonstrable by monoclonal antibodies and that a similar evolution may have occurred in CPV in Vietnam.