Total Synthesis of Trapoxin A, a Fungal HDAC Inhibitor from Helicoma ambiens
Total Synthesis of Trapoxin A, a Fungal HDAC Inhibitor from Helicoma ambiens
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DOI：
10.1021/acs.joc.8b01569
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发表时间：
2018-09-21
影响因子：
3.6
通讯作者：
Kazmaier, Uli
中科院分区：
文献类型：
--
作者：
Servatius, Phil;Kazmaier, Uli
Peptide modification reactions, e.g., via palladium-catalyzed allylic alkylations, are useful tools for the synthesis of peptides containing interesting nonproteinogenic amino acids, which are often essential for the biological activity of natural products and drugs. Herein we report the utilization of such modification reactions in the first total synthesis of trapoxin A, a naturally occurring tetrapeptidic histone deacetylase (HDAC) inhibitor.
