Sex differences in umbilical cord serum levels of inhibin, testosterone, oestradiol, dehydroepiandrosterone sulphate, and sex hormone-binding globulin in human term neonates.
Sex differences in umbilical cord serum levels of inhibin, testosterone, oestradiol, dehydroepiandrosterone sulphate, and sex hormone-binding globulin in human term neonates.
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人类足月新生儿脐带血清中抑制素、睾酮、雌二醇、硫酸脱氢表雄酮和性激素结合球蛋白水平的性别差异。
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发表时间：
1994
期刊：
影响因子：
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通讯作者：
B. Knox
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作者：
D. Simmons;J. France;J. Keelan;L. Song;B. Knox
胎儿在人类妊娠期间对抑制素产生的作用尚不清楚。以前的研究已经报道了脐带血中抑制素的浓度，但样本数有限。本研究是对足月脐血中免疫活性抑制素和类固醇激素的性别差异的更广泛的研究。男性静脉血抑制素浓度(平均值+/-SD 2,168+/-914 pg/ml，n=62)显著高于女性(1,761+/-951 pg/ml，n=63)(p<；0.01)。男性的总睾酮(p<；0.005)、游离睾酮(p<；0.005)和雌二醇(p<；0.005)的浓度也显著高于男性。男性和女性的脱氢表雄酮硫酸盐(DHEAS)浓度和性激素结合球蛋白(SHBG)能力相似。多元回归分析显示，男性的抑制素浓度与睾酮浓度相关，而女性的抑制素浓度不仅与睾酮浓度相关，而且还与分娩时的孕周和SHBG容量有关(均P<；0.001)。24名男性和31名女性脐动脉血清抑制素浓度高于静脉血清，但差异无统计学意义。22例女性脐动脉血DHEAs浓度(6.0/-2.5mumol/L)显著高于静脉血DHEAs浓度(5.2/-1.8mumol/L)(p<；0.0 5)。抑制素与DHEAS的动脉血药浓度或动静脉血药浓度差异均无相关性。这项研究的发现与胎盘是人类妊娠晚期胎儿体内循环抑制素的主要来源是一致的。
The contribution of the fetus to inhibin production in human pregnancy is unclear. Previous studies have reported inhibin concentrations in cord blood but on limited sample numbers. The present study is a more extensive examination of sex differences in immunoreactive inhibin and steroidal hormones in term umbilical cord blood. Venous serum concentrations of inhibin were found to be significantly higher in males (mean +/- SD 2,168 +/- 914 pg/ml, n = 62) than in females (1,761 +/- 951 pg/ml, n = 63) (p < 0.01). Male concentrations of total testosterone (p < 0.005), free testosterone (p < 0.005), and estradiol (p < 0.05) were also significantly higher. The concentration of dehydroepiandrosterone sulphate (DHEAS) and the sex hormone-binding globulin (SHBG) capacity were similar in males and females. Multivariate regression analysis showed that the inhibin concentration in males correlated with the testosterone concentration and in females it correlated not only with testosterone concentration but also with gestational age at delivery and SHBG capacity (all p < 0.001). Inhibin concentrations in cord arterial serum in a subgroup of 24 males and 31 females were higher than in the venous serum in both sexes but the differences were not statistically significant. Concentrations of DHEAS determined in 22 female cord arterial blood samples (6.0 +/- 2.5 mumol/l) were significantly higher than the venous concentrations (5.2 +/- 1.8 mumol/l) (p < 0.05). Inhibin did not correlate with DHEAS either in their arterial serum concentrations or in the arteriovenous concentration differences. The findings of this study are consistent with the placenta being the principal source of inhibin circulating in the human fetus in late pregnancy.(ABSTRACT TRUNCATED AT 250 WORDS)