The association between phthalates and metabolic syndrome: the National Health and Nutrition Examination Survey 2001-2010.
The association between phthalates and metabolic syndrome: the National Health and Nutrition Examination Survey 2001-2010.
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DOI：
10.1186/s12940-016-0136-x
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发表时间：
2016-04-14
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影响因子：
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通讯作者：
Saxena AR
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作者：
James-Todd TM;Huang T;Seely EW;Saxena AR
高暴露于某些邻苯二甲酸酯与糖尿病和胰岛素抵抗有关，性别差异明显。然而，邻苯二甲酸酯与代谢综合征（MetS）之间的关系知之甚少，特别是考虑到性别和绝经状态的差异。我们分析了2001-2010年国家健康与营养调查（NHANES）中2719名年龄在20-80岁的参与者的数据。疾病控制与预防中心分析了五种尿邻苯二甲酸酯代谢物（MEP、MnBP、MiBP、MBzP和MCPP）和DEHP代谢物，并按人群特异性四分位数进行了评估。MetS由国家胆固醇教育计划成人治疗小组III报告标准定义。使用多变量逻辑回归计算患病率优势比（POR）和95%置信区间（CI），调整潜在混杂因素并按性别和绝经状态分层。met患者（占研究人群的32%）尿中所有邻苯二甲酸盐代谢物浓度较高。经过全面调整后，较高的DEHP代谢物浓度与男性met发生率增加相关，但与女性无关（男性的adj. POR Q4 vs Q1: 2.20; 95% CI: 1.32, 3.68；女性的adj. POR Q4 vs Q1: 1.50; 95% CI: 0.89, 2.52）。当评估绝经状态时，与MBzP浓度最低的绝经前妇女相比，MBzP浓度较高的绝经前妇女患MetS的几率增加了近4倍（adj POR: Q4对Q1: 3.88; 95% CI: 1.59, 9.49）。某些邻苯二甲酸酯代谢物浓度较高与MetS的几率增加有关。较高的DEHP代谢物浓度与男性met的几率增加有关。在女性中，较高浓度的MBzP和MetS之间的相关性最强，但仅限于绝经前女性。本文的在线版本（doi:10.1186/s12940-016-0136-x）包含补充材料，可供授权用户使用。
Higher exposure to certain phthalates is associated with a diabetes and insulin resistance, with sex differences seen. Yet, little is known about the association between phthalates and metabolic syndrome (MetS), particularly with consideration for differences by sex and menopausal status. We analyzed data from 2719 participants in the National Health and Nutrition Examination Survey (NHANES) 2001–2010 aged 20–80 years. Five urinary phthalate metabolites (MEP, MnBP, MiBP, MBzP, and MCPP) and DEHP metabolites were analyzed by the Centers for Disease Control and Prevention and were evaluated as population-specific quartiles. MetS was defined by National Cholesterol Education Program’s Adult Treatment Panel III report criteria. Prevalence odds ratios (POR) and 95 % confidence intervals (CI) were calculated using multivariable logistic regression, adjusting for potential confounders and stratifying by sex and menopausal status. Participants with MetS (32 % of the study population) had higher concentrations for all urinary phthalate metabolites. After full adjustment, higher DEHP metabolite concentrations were associated with an increased odds of MetS in men, but not women (adj. POR for men Q4 versus Q1: 2.20; 95 % CI: 1.32, 3.68 and adj. POR for women Q4 versus Q1: 1.50; 95 % CI: 0.89, 2.52). When evaluating by menopausal status, pre-menopausal women with higher concentrations of MBzP had close to a 4-fold increased odds of MetS compared to pre-menopausal women with the lowest concentrations of MBzP (adj POR: Q4 versus Q1: 3.88; 95 % CI: 1.59, 9.49). Higher concentrations of certain phthalate metabolites were associated with an increased odds of MetS. Higher DEHP metabolite concentrations were associated with an increased odds of MetS for men. In women, the strongest association was between higher concentrations of MBzP and MetS, but only among pre-menopausal women. The online version of this article (doi:10.1186/s12940-016-0136-x) contains supplementary material, which is available to authorized users.