The Effects of Nicotine on PGI2 Production by Rat Aortic Endothelium
The Effects of Nicotine on PGI2 Production by Rat Aortic Endothelium
复制标题
尼古丁对大鼠主动脉内皮生成 PGI2 的影响
DOI：
10.1055/s-0038-1657876
复制
发表时间：
1985
影响因子：
6.7
通讯作者：
S. Machin
中科院分区：
文献类型：
--
作者：
H. Bull;R. Pittilo;D. J. Blow;C. M. Blow;P. Rowles;N. Woolf;S. Machin
研究了单次皮下注射尼古丁和连续皮下注射尼古丁7天后大鼠主动脉环产生前列环素的情况。与对照组相比，单次皮下注射1、5、10或20 mg/kg的尼古丁对大鼠主动脉环产生的前环素没有影响。然而，以每小时1 μl的速度连续皮下注射0.54 g/ml尼古丁7天后获得的主动脉环产生的前列环素明显少于对照组动物。
Summary The production of prostacyclin by rat aortic rings was measured following administration of nicotine by a single subcutaneous injection and after continuous subcutaneous infusion over 7 days. Single subcutaneous injections of nicotine at 1, 5, 10 or 20 mg/kg had no effect on prostacyclin production by rat aortic rings in comparison with controls. However, aortic rings obtained after 7 days continuous subcutaneous infusion of 0.54 g/ml of nicotine at the rate of 1 μl per hour produced significantly less prostacyclin than control animals.