Protective Immunity and New Vaccines for Lyme Disease
Protective Immunity and New Vaccines for Lyme Disease
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DOI：
10.1093/cid/ciz872
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发表时间：
2020-04-15
影响因子：
11.8
通讯作者：
Schutzer, Steven E.
中科院分区：
文献类型：
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作者：
Gomes-Solecki, Maria;Arnaboldi, Paul M.;Schutzer, Steven E.
由某些伯氏疏螺旋体引起的莱姆病是北半球最常见的蜱传疾病，病例数量和地理传播仍在继续增长。先前鉴定的伯氏疏螺旋体蛋白、脂质免疫原和活突变体主导了旨在破坏宿主感染的规范疫苗的设计。第一种疫苗的作用机制的发现促进了莱姆病控制新策略的发展，这些策略绕过了人类宿主的直接疫苗接种。因此，新的预防概念集中在蜱虫运输过程中伯氏疏螺旋体产生的蛋白质以及介导摄食和病原体传播的蜱虫蛋白质上。蜱虫免疫是一个新兴的研究领域，因为它可以解锁可能被破坏的机制途径。研究揭示了在蜱传播的伯氏疏螺旋体感染过程中参与的哺乳动物免疫途径，将进一步制定针对莱姆病的疫苗接种策略。
Lyme disease, caused by some Borrelia burgdorferi sensu lato, is the most common tick-borne illness in the Northern Hemisphere and the number of cases, and geographic spread, continue to grow. Previously identified B. burgdorferi proteins, lipid immunogens, and live mutants lead the design of canonical vaccines aimed at disrupting infection in the host. Discovery of the mechanism of action of the first vaccine catalyzed the development of new strategies to control Lyme disease that bypassed direct vaccination of the human host. Thus, novel prevention concepts center on proteins produced by B. burgdorferi during tick transit and on tick proteins that mediate feeding and pathogen transmission. A burgeoning area of research is tick immunity as it can unlock mechanistic pathways that could be targeted for disruption. Studies that shed light on the mammalian immune pathways engaged during tick-transmitted B. burgdorferi infection would further development of vaccination strategies against Lyme disease.