Central aortic blood pressure and augmentation index during normal pregnancy
Central aortic blood pressure and augmentation index during normal pregnancy
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DOI：
10.1038/hr.2012.1
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发表时间：
2012-06-01
影响因子：
5.4
通讯作者：
Kimura, Tadashi
中科院分区：
文献类型：
--
作者：
Fujime, Mika;Tomimatsu, Takuji;Kimura, Tadashi
本研究验证了以下假设：妊娠相关变化在中心血流动力学中更明显，并且在正常妊娠受试者中，中心主动脉收缩压（cSBP）和增强指数（AIx）均独立于肱动脉收缩压（bSBP）。在830例妊娠12 ~ 36周的健康孕妇中，我们使用自动压平眼压测量系统通过桡动脉的脉搏波形无创地测量cSBP和AIx-75（心率为75次/min时的AIx）。在69名孕妇中，我们纵向记录了这些数据。cSBP和AIx-75在妊娠期间显著下降，在妊娠中期达到最低点，并在足月时上升。妊娠相关变化在AIx-75中比cSBP更明显，但在bSBP中不太明显。AIx-75，而不是cSBP，是独立的bSBP在整个怀孕。在35岁以上的健康孕妇中，cSBP和AIx-75显著升高，而bSBP无显著升高。这项研究建立了正常值的脉搏波分析参数在整个怀孕期间，并表明脉搏波分析可能提供额外的和独立的信息，母体动脉顺应性，以传统的肱动脉血压测量。这些数据可用作进一步调查脉搏波分析在评估，管理和预测疾病中的作用的基础，这些疾病可能会干扰妊娠相关的心血管适应。高血压研究（2012）35，633-638; doi：10.1038/hr.2012.1;在线发表2012年2月2日
The current study tested the hypothesis that pregnancy-related changes are more pronounced in central hemodynamics, and both central aortic systolic blood pressure (cSBP) and augmentation index (AIx) are independent from brachial systolic blood pressure (bSBP) in normal pregnant subjects. In 830 healthy pregnant women from 12 to 36 weeks gestation, we measured cSBP and AIx-75 (AIx at heart rate of 75 beats per minute) non-invasively by pulse waveforms of the radial artery using an automated applanation tonometric system. In 69 pregnant women, we recorded these data longitudinally. cSBP and AIx-75 significantly declined during pregnancy, reaching its nadir in mid-pregnancy and rising towards term. Pregnancy-related changes were more pronounced in AIx-75 compared with cSBP, but less evident in bSBP. AIx-75, but not cSBP, was independent from bSBP throughout pregnancy. cSBP and AIx-75, but not bSBP, were significantly increased in healthy pregnant women older than 35 years. This study established normal values for pulse wave analysis parameters throughout pregnancy, and indicated that pulse wave analysis might offer additional and independent information about maternal arterial compliance to conventional brachial blood pressure measurements. These data may be used as the basis for further investigation into the role of pulse wave analysis in the assessment, management and prediction of disorders, which might interfere with pregnancy-related cardiovascular adaptations. Hypertension Research (2012) 35, 633-638; doi:10.1038/hr.2012.1; published online 2 February 2012