Imitation Switch chromatin remodeling factors and their interacting RINGLET proteins act together in controlling the plant vegetative phase in Arabidopsis
Imitation Switch chromatin remodeling factors and their interacting RINGLET proteins act together in controlling the plant vegetative phase in Arabidopsis
复制标题
模拟开关染色质重塑因子及其相互作用的 RINGLET 蛋白共同作用控制拟南芥植物营养期
DOI：
10.1111/j.1365-313x.2012.05074.x
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发表时间：
2012-10-01
期刊：
影响因子：
7.2
通讯作者：
Xu, Lin
中科院分区：
文献类型：
--
作者：
Li, Guang;Zhang, Jiawei;Xu, Lin
在其生命周期中，开花植物必须经历从营养生长到生殖生长的过渡。在这里，我们报告说，双突变的拟南芥模仿拟南芥（AtISWI）基因，染色质重塑11（CHR 11）和CHR 17，和植物特异性的DDT-域包含基因，RINGLET 1（RLT 1）和RLT 2，导致植物具有类似的发育缺陷，包括显着加速的植物生殖过渡。我们证明了AtISWI与RLT在物理上相互作用，通过调节几个关键基因来防止植物提前激活植物到生殖的过渡，这些基因有助于开花时间。特别地，AtISWI和RLT抑制FT、SEP 1、SEP 3、FUL和SOC 1，但促进叶中的FLC。此外，AtISWI和RLT可能通过与FT和SEP 3位点的结合直接抑制FT和SEP 3。我们的研究表明，AtISWI和RLT代表了一个以前未被认识到的遗传途径，这是维持植物营养期所必需的。
During their life cycle, flowering plants must experience a transition from vegetative to reproductive growth. Here, we report that double mutations in the Arabidopsis thaliana IMITATION SWITCH (AtISWI) genes, CHROMATIN REMODELING11 (CHR11) and CHR17, and the plant-specific DDT-domain containing genes, RINGLET1 (RLT1) and RLT2, resulted in plants with similar developmental defects, including the dramatically accelerated vegetative-to-reproductive transition. We demonstrated that AtISWI physically interacts with RLTs in preventing plants from activating the vegetative-to-reproductive transition early by regulating several key genes that contribute to flower timing. In particular, AtISWI and RLTs repress FT, SEP1, SEP3, FUL, and SOC1, but promote FLC in the leaf. Furthermore, AtISWI and RLTs may directly repress FT and SEP3 through associating with the FT and SEP3 loci. Our study reveals that AtISWI and RLTs represent a previously unrecognized genetic pathway that is required for the maintenance of the plant vegetative phase.