Can Analysis of Routine Viral Testing Provide Accurate Estimates of Respiratory Syncytial Virus Disease Burden in Adults?
Can Analysis of Routine Viral Testing Provide Accurate Estimates of Respiratory Syncytial Virus Disease Burden in Adults?
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DOI：
10.1093/infdis/jix196
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发表时间：
2017-06-01
影响因子：
6.4
通讯作者：
Falsey, Ann R.
中科院分区：
文献类型：
--
作者：
Datta, Siddhant;Walsh, Edward E.;Falsey, Ann R.
呼吸道合胞病毒（RSV）越来越被认为是成人呼吸道疾病的重要原因。我们评价了常规病毒检测和出院诊断，以确定RSV和流感负荷。回顾了成人在急诊室就诊或住院期间进行的聚合酶链反应结果。RSV活性峰值先于流感活性8周。流感期间进行的病毒检测总数除以呼吸道访视总数的比值高于RSV高峰期（1.31 vs 0.72; P =.0001）。流感和RSV分别为56例（30%）和7例（6%）（P < .0001）。常规病毒检测估计成人RSV疾病负担有局限性。
Respiratory syncytial virus (RSV) is increasingly recognized as a significant cause of adult respiratory illness. We evaluated routine viral testing and discharge diagnoses for identifying RSV and influenza burden. Polymerase chain reaction results performed in adults during emergency room visits or hospitalizations were reviewed. Peak RSV activity preceded influenza activity by 8 weeks. The ratio of total number of viral tests performed divided by total number of respiratory visits was higher during influenza than RSV peaks (1.31 vs 0.72; P =.0001). Influenza and RSV were listed primary diagnoses in 56 (30%) vs 7 (6%), respectively (P < .0001). Routine viral testing to estimate adult RSV disease burden has limitations.