Early and Degressive Putamen Atrophy in Multiple Sclerosis.
Early and Degressive Putamen Atrophy in Multiple Sclerosis.
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DOI：
10.3390/ijms161023195
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发表时间：
2015-09-25
影响因子：
5.6
通讯作者：
Deppe M
中科院分区：
文献类型：
--
作者：
Krämer J;Meuth SG;Tenberge JG;Schiffler P;Wiendl H;Deppe M
近年来，多发性硬化症（MS）患者的壳核萎缩及其在病程中的长期进展。在这里，我们回顾性研究了复发缓解型MS（RRMS）患者萎缩发作的时间点。在一项横断面研究中，68例RRMS患者和26例健康对照（HC）接受了3T MRI检查。通过校正年龄和颅内容积（ICV），我们定量分析了个体患者的壳核体积与疾病持续时间的关系。与HC相比，患者的相对壳核体积（RPV）（以ICV的百分比表示）显著降低。基于RPV与年龄的相关性，我们计算了HC的年龄校正RPV偏差（ΔRPV）。患者的ΔRPV显著为负值。有趣的是，年龄校正后的ΔRPV依赖于疾病持续时间：在首次出现症状后，患者已经显示出RPV降低，随后体积进一步递减。这意味着萎缩进展在疾病的第一年比以后几年更强。壳膜萎缩在最初的症状表现后直接开始，甚至在几年前开始，并以递减的方式进展。由于其在神经功能中的重要作用，早期发现壳核萎缩似乎是必要的。高分辨率结构MRI可以监测疾病进程。
Putamen atrophy and its long-term progress during disease course were recently shown in patients with multiple sclerosis (MS). Here we investigated retrospectively the time point of atrophy onset in patients with relapsing-remitting MS (RRMS). 68 patients with RRMS and 26 healthy controls (HC) were admitted to 3T MRI in a cross-sectional study. We quantitatively analyzed the putamen volume of individual patients in relation to disease duration by correcting for age and intracranial volume (ICV). Patient’s relative putamen volume (RPV), expressed in percent of ICV, was significantly reduced compared to HC. Based on the correlation between RPV and age, we computed the age-corrected RPV deviation (ΔRPV) from HC. Patients showed significantly negative ΔRPV. Interestingly, the age-corrected ΔRPV depended logarithmically on disease duration: Directly after first symptom manifestation, patients already showed a reduced RPV followed by a further degressive volumetric decline. This means that atrophy progression was stronger in the first than in later years of disease. Putamen atrophy starts directly after initial symptom manifestation or even years before, and progresses in a degressive manner. Due to its important role in neurological functions, early detection of putamen atrophy seems necessary. High-resolution structural MRI allows monitoring of disease course.