Alcohol effects on γ-aminobutyric acid type A receptors:: are extrasynaptic receptors the answer?
Alcohol effects on γ-aminobutyric acid type A receptors:: are extrasynaptic receptors the answer?
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DOI：
10.1016/j.lfs.2004.05.035
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发表时间：
2004-11-19
期刊：
影响因子：
6.1
通讯作者：
Olsen, RW
中科院分区：
文献类型：
--
作者：
Hanchar, HJ;Wallner, M;Olsen, RW
GABA（A）受体长期以来被认为介导了乙醇在哺乳动物脑中的至少部分作用。然而，直到最近，报告的行动，乙醇重组受体需要非常高剂量的乙醇和动物缺乏受体亚基显示是重要的乙醇行动在体外不支持的观点，这些亚基是至关重要的乙醇行动。重组α 4 β 3 δ和α 6 β 3 δ GABA（A）受体对乙醇具有独特的敏感性，其剂量-反应关系反映了饮酒对人类大脑的众所周知的影响。含有6亚基的受体被认为位于突触外，并且确定这些突触外GABA（A）受体亚基组合是否介导体内低剂量酒精效应将是重要的。(C)2004年爱思唯尔公司All rights reserved.
GABA(A) receptors have long been implicated in mediating at least part of the actions of ethanol in mammalian brain. However, until very recently, reports of the actions of EtOH on recombinant receptors have required very high doses of ethanol and animals lacking receptor subunits shown to be important for ethanol actions in vitro did not support the view that these subunits are crucial in ethanol actions. Recombinant alpha4beta3delta and alpha6beta3delta GABA(A) receptors are uniquely sensitive to ethanol, with a dose-response relationship mirroring the well known effects of alcohol consumption on the human brain. Receptors containing the 6 subunit are thought to be located extrasynaptically and it will be important to determine if these extrasynaptic GABA(A) receptor subunit combinations mediate low dose alcohol effects in vivo. (C) 2004 Elsevier Inc. All rights reserved.