Normal values of urinary excretion and serum concentration of 5‐S‐cysteinyldopa and 6‐hydroxy‐ 5‐methoxyindole‐2‐carboxylic acid, biochemical markers of melanoma progression
Normal values of urinary excretion and serum concentration of 5‐S‐cysteinyldopa and 6‐hydroxy‐ 5‐methoxyindole‐2‐carboxylic acid, biochemical markers of melanoma progression
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5-S-半胱氨酰多巴和 6-羟基-5-甲氧基吲哚-2-羧酸的尿排泄和血清浓度的正常值，黑色素瘤进展的生化标志物
DOI：
10.1097/00008390-199106000-00009
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发表时间：
1991
影响因子：
2.2
通讯作者：
T. Horikoshi
中科院分区：
文献类型：
--
作者：
K. Wakamatsu;S. Ito;T. Horikoshi
尿中排出的褐黑素前体5-S-半胱氨酰多巴（5-S-CD）已被用作转移性黑色素瘤的肿瘤标志物。在某些黑色素瘤患者中，与真黑素相关的代谢物6-羟基-5-甲氧基吲哚-2-羧酸（6 H5 MI 2C）也以高水平排泄。为了比较正常值，我们测定了33名日本正常人的尿排泄和血清5-S-CD和6 H5 MI 2C浓度。尿中5-S-CD和6 H5 MI 2C的平均值分别为0.45和0.39 μmol/d，血清中为4.3和3.6 nmol/l。尿液中这些标记物的水平比血清中的水平变化更大。我们采用1.5 μmol/天和10 nmol/l作为两种标志物的尿排泄和血清浓度正常范围的上限。男性和女性之间没有显著差异。四个标记之间没有相关性。与中年受试者相比，老年受试者尿中两种标记物的排泄量均显著降低，而血清浓度无年龄依赖性差异。这些结果表明，血清中的5− S-CD和6 H5 MI 2C水平作为估计黑色素瘤进展的肿瘤标志物比尿液中的水平更可靠。
The urinary excretion of the pheomelanin precursor 5− S-cysteinyldopa (5-S-CD) has been used as a tumour marker for metastatic melanoma. The eumelanin-re-lated metabolite 6-hydroxy-5-methoxyindole-2− carboxylic acid (6H5MI2C) is also excreted at high levels in some melanoma patients. In order to compare normal values, we measured urinary excretion and serum concentration of 5-S-CD and 6H5MI2C in 33 Japanese normal subjects. The mean values of 5-S-CD and 6H5MI2C in urine were 0.45 and 0.39 μmol/day, respectively, and those in serum 4.3 and 3.6 nmol/l. Levels of these markers in urine were much more variable than those in serum. We have adopted 1.5 μmol/day and 10 nmol/l as the upper limits for normal ranges of the urinary excretion and serum concentration, for both markers. No significant differences were found between men and women. There were no correlations among the four markers. The urinary excretion of both markers showed significant decrease in elderly subjects as compared with middle-aged subjects, while the serum concentration showed no age-dependent differences. These results suggest that the levels of 5− S-CD and 6H5MI2C in serum are more reliable as tumour markers for the estimation of melanoma progression than those in urine.