Cross-Sectional Associations of Computed Tomography (CT)-Derived Adipose Tissue Density and Adipokines: The Framingham Heart Study.
Cross-Sectional Associations of Computed Tomography (CT)-Derived Adipose Tissue Density and Adipokines: The Framingham Heart Study.
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DOI：
10.1161/jaha.115.002545
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发表时间：
2016-02-29
影响因子：
5.4
通讯作者：
Fox CS
中科院分区：
文献类型：
--
作者：
Lee JJ;Pedley A;Hoffmann U;Massaro JM;Keaney JF Jr;Vasan RS;Fox CS
腹部皮下（SAT）和内脏脂肪组织（VAT）的过量积累与脂肪因子的不良水平和心血管疾病风险相关。脂肪质量是否与脂肪因子相关尚未确定。这项研究检查了腹部 SAT 和 VAT 密度（脂肪质量的间接测量）之间的关联，以及一组由脂肪组织或肝脏分泌的代谢调节生物标志物，与绝对脂肪体积无关。我们评估了 1829 名弗雷明汉心脏研究参与者（44.9% 为女性）。使用计算机断层扫描通过脂肪组织衰减间接估计腹部 SAT 和 VAT 密度。脂肪因子包括脂联素、瘦素受体、瘦素、脂肪酸结合蛋白 4 (FABP-4)、视黄醇结合蛋白 4 (RBP-4) 和胎球蛋白-A。除胎球蛋白-A 外，脂肪密度与所有评估的生物标志物相关。较低的脂肪密度（即更多的负脂肪衰减）与较低的脂联素和瘦素受体相关，但与较高的瘦素和 FABP-4 水平相关（所有 P<0.0001）。在两性中，SAT 密度与 RPB-4 呈负相关，而 VAT 密度与 RPB-4 之间的关联仅在男性中观察到（P<0.0001）。在女性中，在对各自的脂肪量进行额外调整后，SAT 密度保留了与脂联素、瘦素、FABP-4 和 RBP-4 的显着相关性；和仅使用脂联素的增值税密度（所有 P<0.0001）。在男性中，在对各自的脂肪体积进行额外调整后仍保持显着的关联（P<0.005）。下腹部脂肪密度与提示较高心脏代谢风险的生物标志物特征相关。这些观察结果支持脂肪密度可能是心脏代谢风险的有效生物标志物。
Excess accumulation of abdominal subcutaneous (SAT) and visceral adipose tissue (VAT) is associated with adverse levels of adipokines and cardiovascular disease risk. Whether fat quality is associated with adipokines has not been firmly established. This study examined the association between abdominal SAT and VAT density, an indirect measure of fat quality, with a panel of metabolic regulatory biomarkers secreted by adipose tissue or the liver independently of absolute fat volumes. We evaluated 1829 Framingham Heart Study participants (44.9% women). Abdominal SAT and VAT density was estimated indirectly by adipose tissue attenuation using computed tomography. Adipokines included adiponectin, leptin receptor, leptin, fatty acid‐binding protein 4 (FABP‐4), retinol‐binding protein 4 (RBP‐4), and fetuin‐A. Fat density was associated with all the biomarkers evaluated, except fetuin‐A. Lower fat density (ie, more‐negative fat attenuation) was associated with lower adiponectin and leptin receptor, but higher leptin and FABP‐4 levels (all P<0.0001). SAT density was inversely associated with RPB‐4 in both sexes, whereas the association between VAT density and RPB‐4 was only observed in men (P<0.0001). In women, after additional adjustment for respective fat volume, SAT density retained the significant associations with adiponectin, leptin, FABP‐4, and RBP‐4; and VAT density with adiponectin only (all P<0.0001). In men, significant associations were maintained upon additional adjustment for respective fat volume (P<0.005). Lower abdominal fat density was associated with a profile of biomarkers suggestive of greater cardiometabolic risk. These observations support that fat density may be a valid biomarker of cardiometabolic risk.