N-Cadherin Orchestrates Self-Organization of Neurons within a Columnar Unit in the Drosophila Medulla
N-Cadherin Orchestrates Self-Organization of Neurons within a Columnar Unit in the Drosophila Medulla
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DOI：
10.1523/jneurosci.3107-18.2019
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发表时间：
2019-07-24
影响因子：
5.3
通讯作者：
Sato, Makoto
中科院分区：
文献类型：
--
作者：
Trush, Olena;Liu, Chuyan;Sato, Makoto
柱状结构是大脑的基本单位，但其发育机制在很大程度上仍然未知。髓质，最大的神经节的果蝇视觉中心，提供了一个独特的机会来揭示的三维组织的列的机制。在这项研究中，使用N-cadherin（Ncad）作为标记，我们揭示了甜甜圈状柱状结构沿着在幼虫髓质的二维层，演变形成三个不同的层在蛹的发展。柱形成由三个核心神经元R8、R7和Mil启动，它们在柱内建立不同的同心结构域。我们表明，Ncad依赖的相对的核心柱状神经元的调节其相对位置内的列沿着在幼虫髓质的二维层根据差分粘附假说。我们还提出了存在的相互作用的三个层之间的形成过程中的3D结构的髓质柱。
Columnar structure is a basic unit of the brain, but the mechanism underlying its development remains largely unknown. The medulla, the largest ganglion of the Drosophila melanogaster visual center, provides a unique opportunity to reveal the mechanisms of 3D organization of the columns. In this study, using N-cadherin (Ncad) as a marker, we reveal the donut-like columnar structures along the 2D layer in the larval medulla that evolves to form three distinct layers in pupal development. Column formation is initiated by three core neurons, R8, R7, and Mil, which establish distinct concentric domains within a column. We demonstrate that Ncad-dependent relative adhesiveness of the core columnar neurons regulates their relative location within a column along a 2D layer in the larval medulla according to the differential adhesion hypothesis. We also propose the presence of mutual interactions among the three layers during formation of the 3D structures of the medulla columns.