Appenolides A-C: three new antifungal furanones from the coprophilous fungus Podospora appendiculata.
Appenolides A-C: three new antifungal furanones from the coprophilous fungus Podospora appendiculata.
复制标题
Appenolides A-C：来自粪生真菌 Podosporaappiculata 的三种新型抗真菌呋喃酮。
DOI：
10.1021/np50093a005
复制
发表时间：
1993
影响因子：
5.1
通讯作者：
Malloch,D
中科院分区：
文献类型：
--
作者：
Wang,Y;Gloer,JB;Scott,JA;Malloch,D
Appenolides A [1], B [2], and C [3], three new antifungal 2 (5H)-furanones, have been isolated from liquid cultures of the coprophilous fungus Podospora appen-diculata (UAMH 7225) by repeated preparative tic on Si gel. The structures were assigned on the basis of nmr and ms data.Interspecies competition among coprophilous (dung-colonizing) fungi has been ob-served (1, 2) and may play an important role in the pattern of colonization and succes-sional changes within the corresponding fungal ecosystem. There is increasing evidence that chemical investigation of such species can lead to the discovery of novel antifungal compounds (3—7). During our continuing search for new antifungal agents from cop-rophilous fungi, we found that organic extracts of cultures of Podospora appendiculata (Awd. ex Niessl) Niessl (Sordariaceae) exhibited both antibacterial and antifungal effects. This report describes the isolation and structure determination of three new antifungal 2 (5H)-furanones 1—3 from these extracts. Naturally occurring fiiranones are not uncommon, and members of this class have been reported to exhibit a variety of biological activities (8—13).
