Vitreous fluid levels of β-amyloid(1-42) and tau in patients with retinal diseases
Vitreous fluid levels of β-amyloid(1-42) and tau in patients with retinal diseases
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DOI：
10.1007/s10384-004-0156-x
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发表时间：
2005-03-01
影响因子：
2.4
通讯作者：
Tanihara, H
中科院分区：
文献类型：
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作者：
Yoneda, S;Hara, H;Tanihara, H
据报道，脑脊液中β -淀粉样蛋白（1-42）（A β 42）的减少和tau蛋白的增加是阿尔茨海默病患者的特征性现象。为了验证A - 42和tau蛋白与视网膜疾病发展有关的观点，我们测量了黄斑孔（n = 13）、糖尿病视网膜病变（n = 15）或伴有其他眼部疾病的青光眼（n = 8）患者玻璃体液中的A - 42和tau蛋白浓度。方法：采集玻璃体切除术患者的玻璃体标本。，并采用敏感和特异性酶联免疫吸附法测定A β 42和tau的浓度。结果:相比之下的水平控制视网膜病人(33.9 + / - 7.1 pg / mlβ42;3.3 + / - 3.2 pg / mlτ),有一个显著减少β42级和显著增加τ级患者的糖尿病性视网膜病变(1.8 + / - 1.9 pg / mlβ42,P 0.002; 153.7 + / - 71.6 pg / mlτ,P 0.041)与其他眼部疾病或青光眼并发(2.8 + / - 1.8 pg / mlβ42,P = 0.006; 113.6 + / - 43.1 pg / mlτ,P = 0.023)。结论：我们的研究结果提示a β 42和tau可能在一些视网膜疾病的发病机制中起作用。(c)日本眼科学会，2005年。
A decrease in beta-amyloid(1-42) (A beta 42) and an increase in tau in the cerebrospinal fluid are reported to be characteristic phenomena in Alzheimer's disease patients. To test the idea that A 42 and tau contribute to the development of retinal diseases, we measured A beta 42 and tau concentrations in the vitreous fluid from patients with macular hole (n = 13), diabetic retinopathy (n = 15), or glaucoma concurrent with other ocular diseases (n = 8).Methods: Vitreous samples were collected from patients who underwent vitrectomy., and sensitive and specific enzyme-linked immunosorbent assays were used to determine the concentrations of A beta 42 and tau.Results: By comparison with the levels in the control macular-hole patients (33.9 +/- 7.1 pg/ml for A beta 42; 3.3 +/- 3.2pg/ml for tau), there was a significant decrease in the A beta 42 level and a significant increase in the tau level in patients with diabetic retinopathy (1.8 +/- 1.9pg/ml for A beta 42, P 0.002; 153.7 +/- 71.6 pg/ml for tau, P 0.041) or glaucoma concurrent with other ocular diseases (2.8 +/- 1.8 pg/ml for A beta 42, P = 0.006; 113.6 +/- 43.1 pg/ml for tau, P = 0.023).Conclusions: Our findings indicate the possibility of a role for A beta 42 and tau in the pathogenesis of some retinal diseases. (c) Japanese Ophthalmological Society 2005.