The Dietary Inflammatory Index Is Associated with Colorectal Cancer Risk in the Multiethnic Cohort
The Dietary Inflammatory Index Is Associated with Colorectal Cancer Risk in the Multiethnic Cohort
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DOI：
10.3945/jn.116.242529
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发表时间：
2017-03-01
影响因子：
4.2
通讯作者：
Hebert, James R.
中科院分区：
文献类型：
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作者：
Harmon, Brook E.;Wirth, Michael D.;Hebert, James R.
背景：饮食已知会影响全身炎症，而全身炎症是公认的结直肠癌(CRC)的危险因素。在不同种族人群中检验饮食炎症潜能与结直肠癌发病率之间关系的研究是有限的。目的：我们使用饮食炎症指数来阐明饮食炎症潜能与结直肠癌发病率之间的关系。我们假设促炎性饮食会增加结直肠癌的风险，而且这些关联在种族/民族之间可能不同。方法：多民族队列(MEC)遵循前瞻性研究设计。研究对象包括190,963名白人、非洲裔美国人、夏威夷原住民、日裔美国人和拉丁裔美国人，年龄在45-75岁之间，并在20岁以上进行了跟踪调查。参与者完成了一份食物频率问卷，根据问卷计算出能量调整后的饮食炎症指数(E-DII)分数，并将其归类为四分位数。通过与癌症登记项目的链接来记录CRC发病率。结果：在所有参与者中，更多的促炎饮食(最高四分位数与最低四分位数相比)与结直肠癌风险增加相关(HR：1.21；95%CI：1.11，1.32)。然而，男性的效应大小(HR：1.28；95%CI：1.13，1.45)大于女性(HR：1.16；95%CI：1.02，1.33)，尽管性行为的交互作用项没有统计学意义(P-交互作用=0.17)。当按种族/民族分层时，男性组之间的关联显著不同(P-交互作用=0.01)，尽管女性组之间的关联不同(P-交互作用=0.20)。在白人、日裔美国人、拉丁裔男性和夏威夷原住民女性中，观察到与比率在2.33到1.04之间的显著相关性。结论：总体而言，E-DII确定的更促炎饮食与不同种族/民族的MEC参与者中CRC风险的增加有关。这项研究增加了证据表明，高促炎潜力的饮食可能会增加结直肠癌的风险。
Background: Diet is known to influence systemic inflammation, a recognized risk factor for colorectal cancer (CRC). Studies in ethnically diverse populations that examine the association between dietary inflammatory potential and CRC incidence are limited.Objectives: We used the Dietary Inflammatory Index to clarify the relation between the inflammatory potential of diet and CRC incidence across racial/ethnic groups. We hypothesized that proinflammatory diets would be associated with an increased risk of CRC, and that these associations may differ across racial/ethnic groups.Methods: The Multiethnic Cohort (MEC) follows a prospective study design. It includes 190,963 white, African-American, native Hawaiian, Japanese-American, and Latino men and women aged 45-75 y at recruitment and followed over 20 y. Participants completed a food frequency questionnaire from which energy-adjusted Dietary Inflammatory Index (E-DII) scores were computed and categorized into quartiles. CRC incidence was documented through linkage to cancer registry programs. Cox proportional hazards regression was used to estimate HRs and 95% CIs, adjusting for known or expected CRC risk factors.Results: Among all participants, more-proinflammatory diets (highest quartile compared with lowest quartile) were associated with an increased risk of CRC (HR: 1.21; 95% CI: 1.11, 1.32). However, the effect size was larger for men (HR: 1.28; 95% CI: 1.13, 1.45) than for women (HR: 1.16; 95% CI: 1.02, 1.33), although the interaction term for sex was not statistically significant (P-interaction = 0.17). When stratified by race/ethnicity, the association was significantly different between groups for men (P-interaction = 0.01), although not for women (P-interaction = 0.20). Significant associations with HRs ranging from 2.33 to 1.04 were observed in white, Japanese-American, and Latino men, and native Hawaiian women.Conclusions: Overall, more-proinflammatory diets, as identified by the E-DII, were associated with increased CRC risk in MEC participants across racial/ethnic groups. This study adds to the evidence suggesting that dietswith high proinflammatory potential may increase CRC risk.