A Stromal Cell Niche for Human and Mouse Type 3 Innate Lymphoid Cells.
A Stromal Cell Niche for Human and Mouse Type 3 Innate Lymphoid Cells.
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DOI：
10.4049/jimmunol.1402584
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发表时间：
2015-11-01
期刊：
影响因子：
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通讯作者：
Cupedo T
中科院分区：
文献类型：
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作者：
Hoorweg K;Narang P;Li Z;Thuery A;Papazian N;Withers DR;Coles MC;Cupedo T
获得性免疫关键取决于次级淋巴器官的功能区室化。间充质基质细胞产生并维持支持T和B细胞的存活、活化和扩增的特化小生境，并且淋巴细胞及其小生境的综合分析有助于理解适应性免疫。类扁桃体器官也是3型先天淋巴样细胞（ILC3）的家园，这是屏障免疫所必需的先天效应细胞。然而，一个专门的基质生态位ILC3尚未确定。一种新的谱系追踪方法，现在确定了一个子集的小鼠胎儿淋巴组织的组织者细胞，专门产生成人边缘网状细胞（MRC）。此外，这两种细胞类型从小鼠到人都是保守的，并且在整个生命过程中与ILC3共定位于次级淋巴组织中。总之，我们提供的证据表明，胎儿间质组织者引起成人MRC，并形成一个专门的间质生态位先天ILC3在适应性淋巴器官。
Adaptive immunity critically depends on the functional compartmentalization of secondary lymphoid organs. Mesenchymal stromal cells create and maintain specialized niches that support survival, activation and expansion of T and B cells, and integrated analysis of lymphocytes and their niche has been instrumental in understanding adaptive immunity. Lymphoid organs are also home to type 3 innate lymphoid cells (ILC3), innate effector cells essential for barrier immunity. However, a specialized stromal niche for ILC3 has not been identified. A novel lineage-tracing approach now identifies a subset of murine fetal lymphoid tissue organizer cells that gives rise exclusively to adult marginal reticular cells (MRC). Moreover, both cell types are conserved from mouse to human and co-localize with ILC3 in secondary lymphoid tissues throughout life. In sum, we provide evidence that fetal stromal organizers give rise to adult MRC and form a dedicated stromal niche for innate ILC3 in adaptive lymphoid organs.