Effects of a lifestyle intervention on body composition in prostate cancer patients on androgen deprivation therapy.
Effects of a lifestyle intervention on body composition in prostate cancer patients on androgen deprivation therapy.
复制标题
生活方式干预对前列腺癌患者身体成分的影响对雄激素剥夺治疗。
作者：
运动和饮食（EX+D）干预可能是减轻或逆转前列腺癌（PCa）患者雄激素剥夺治疗（ADT）不良反应的最佳治疗方法。个体化饮食和运动依从性先导（IDEA-P）试验比较了EX+D干预相对于标准治疗（SC）在接受ADT的PCa患者中的效果。本研究评价了EX+D干预对IDEA-P患者子样本中通过双能X线吸收测定法（DXA）获得的身体成分（BC）的影响。次要目的是探讨肥胖和瘦体重与运动能力和力量的关系。在基线和3个月随访时，从22例PCa患者（EX+D：n = 13; SC：n = 9）的子样本中获得完整的DXA数据。意向治疗分析包括30名参与者（M年龄= 66.28; SD = 7.79）的基线DXA评估数据。意向治疗分析显示EX+D导致脂肪量的显著改善（P = 0.022），脂肪量百分比（P = 0.028），躯干脂肪量（P = 0.017），脂肪量/瘦体重EX+D组与SC组相比，瘦体重百分比（P = 0.026）也导致了更有利的瘦体重/体重变化（d = 0.59）。在3个月随访时，选择BC结果也与移动性能和力量显著相关（P < 0.05）。研究结果表明，EX+D干预导致相对于SC治疗的瘦肉组织的上级保存和肥胖的改善。结果强调了在接受ADT的PCa患者中实施EX+D干预以保留肌肉质量和减少肥胖的效用。
Exercise and dietary (EX+D) interventions could represent an optimal treatment for attenuating or reversing adverse effects of androgen deprivation therapy (ADT) in prostate cancer (PCa) patients. The Individualized Diet and Exercise Adherence-Pilot (IDEA-P) trial compared the effects of an EX+D intervention relative to standard-of-care (SC) treatment among PCa patients undergoing ADT. The present study evaluated the effects of the EX+D intervention on body composition (BC) obtained via dual-energy X-ray absorptiometry (DXA) in a subsample of IDEA-P patients. A secondary objective was to explore the association of adiposity and lean mass with mobility performance and strength. Complete DXA data were acquired from a subsample of 22 PCa patients (EX+D: n = 13; SC: n = 9) at baseline and 3 month follow-up. Intention-to-treat analysis included data from 30 participants (M age = 66.28; SD = 7.79) with baseline DXA assessments. Intention-to-treat analysis revealed EX+D resulted in significant improvements in fat mass (P = 0.022), per cent fat mass (P = 0.028), trunk fat mass (P = 0.017), fat mass/lean mass (P = 0.040), and per cent lean mass (P = 0.026) vs. SC. EX+D also resulted in more favourable changes in appendicular lean mass/body mass (d = 0.59). Select BC outcomes were also significantly correlated with mobility performance and strength (P < 0.05) at 3 month follow-up. Findings suggest the EX+D intervention resulted in superior preservation of lean tissue and improvement in adiposity relative to SC treatment. Results underscore the utility of implementing EX+D interventions for preserving muscle mass and reducing adiposity in PCa patients undergoing ADT.