Warfarin doses for anticoagulation therapy in elderly patients with chronic atrial fibrillation.
Warfarin doses for anticoagulation therapy in elderly patients with chronic atrial fibrillation.
复制标题
华法林剂量用于慢性心房颤动老年患者的抗凝治疗。
DOI：
10.6061/clinics/2012(06)01
复制
发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Strunz CM
中科院分区：
文献类型：
--
作者：
Mansur Ade P;Takada JY;Avakian SD;Strunz CM
抗凝是预防老年慢性房颤患者血栓栓塞事件的一个挑战。稳定抗凝被定义为在治疗范围的bbb70 %内的时间。然而，达到稳定抗凝所需的剂量仍然未知。本研究的目的是分析老年患者维持稳定口服抗凝治疗所需的华法林剂量。我们分析了112例连续门诊心房颤动患者，年龄≥65岁，接受华法林抗凝治疗1年以上，国际标准化比值稳定在2.0和3.0之间≥6个月。国际归一化比率在中心实验室采用传统方法测定。患者根据以下年龄组进行分层：<75或≥75岁，<80或≥80岁。<75岁或≥75岁患者的华法林平均日剂量相似（3.34±1.71 mg/天vs 3.26±1.27 mg/天，p = 0.794）， <80岁或≥80岁患者的华法林平均日剂量相似（3.36±1.49 mg/天vs 3.15±1.23 mg/天，p = 0.433）。在88例（79%）患者中，华法林的日剂量在2 - 5mg /天之间；13例（11%）患者每日华法林剂量<2.0 mg/天；在11例（10%）患者中，华法林的日剂量为0.5 mg/天。华法林日剂量与国际标准化比值的相关系数为0.22 （p = 0.012）。接受华法林剂量为2 - 5mg /天的患者中，80%的患者抗凝效果稳定，各年龄组的平均日剂量相似。
Anticoagulation is a challenge for the prophylaxis of thromboembolic events in elderly patients with chronic atrial fibrillation. Stable anticoagulation is defined as the time within >70% of the therapeutic range. However, the dosage required to achieve stable anticoagulation remains unknown. The aim of this study was to analyze the warfarin dose necessary for the maintenance of stable oral anticoagulation therapy in elderly patients. We analyzed 112 consecutive outpatients with atrial fibrillation who were ≥65 years of age, had received anticoagulation therapy with warfarin for more than 1 year and had a stable international normalized ratio between 2.0 and 3.0 for ≥6 months. The international normalized ratio was measured in the central laboratory using the traditional method. The patients were stratified according to the following age groups: <75 or ≥75 years and <80 or ≥80 years. The mean daily doses of warfarin were similar for patients <75 or ≥75 years (3.34±1.71 versus 3.26±1.27 mg/day, p = 0.794) and <80 or ≥80 years (3.36±1.49 versus 3.15±1.23 mg/day, p = 0.433). In 88 (79%) patients, the daily warfarin dose was between 2 and 5 mg/day; in 13 (11%) patients, the daily warfarin dose was <2.0 mg/day; and in 11 (10%) patients, the daily warfarin dose was >5.0 mg/day. The correlation between the daily warfarin dose and the international normalized ratio was 0.22 (p = 0.012). Stable anticoagulation was achieved in 80% of patients who received doses of 2 to 5 mg/day of warfarin, and the mean daily dose was similar across the age groups analyzed.
登录
查看更多内容
影响因子：
4.1
作者：
Rudd, Kelly M.;Dier, John G.
通讯作者：
Dier, John G.
影响因子：
158.5
作者：
Kearon, C;Ginsberg, JS;Gent, M
通讯作者：
Gent, M
影响因子：
--
作者：
Baker, William L.;Cios, Deborah A.;Coleman, Craig I.
通讯作者：
Coleman, Craig I.
影响因子：
2.8
作者：
Chan, Paul S.;Maddox, Thomas M.;Tang, Fengming;Spinler, Sarah;Spertus, John A.
通讯作者：
Spertus, John A.
DOI：
10.1161/circoutcomes.108.830232
发表时间：
2009-07
期刊：
Circulation. Cardiovascular quality and outcomes
影响因子：
--
作者：
Singer DE;Chang Y;Fang MC;Borowsky LH;Pomernacki NK;Udaltsova N;Go AS
通讯作者：
Go AS