ProGlycProt V2.0, a repository of experimentally validated glycoproteins and protein glycosyltransferases of prokaryotes
ProGlycProt V2.0, a repository of experimentally validated glycoproteins and protein glycosyltransferases of prokaryotes
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DOI：
10.1093/glycob/cwz013
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发表时间：
2019-06-01
期刊：
影响因子：
4.3
通讯作者：
Rao，Alka
中科院分区：
文献类型：
--
作者：
Choudhary，Pravinkumar;Nagar，Rupa;Rao，Alka
了解蛋白质的糖基化状态和糖链模式具有相当大的医学、学术和应用价值。因此，ProGlycProt V2.0(www.proglcprot.org)被构思和维护为一个独家网络资源，提供关于实验验证的原核糖蛋白和蛋白质糖基转移酶(GTS)的全面信息。ProGlycProt的第二版有一个重大更新，关于这个主题的条目总数增加了191%，这些条目是从607本同行评议的出版物中手动收集和整理的。原核生物中催化多种糖链连接的蛋白质GT是一种顺从的糖工程工具。因此，第二版提供了在两个子数据库中大大扩展和重新组织的内容：ProGPdb和ProGTdb。虽然ProGPdb提供了有关有效糖蛋白的信息(222个条目)，但ProGTdb将有助于蛋白质糖基化的酶/蛋白质分类(122个)或作为辅助蛋白质(182个)。ProGlycProt V2.0仍然高度交叉引用，但与其他相关数据库在内容上是独家的和互补的。第二版进一步具有增强的搜索能力、“比较”条目选项和创新的地理分析工具(MapView)，便于使用ProGlycProt V2.0数据库中引用的研究人员/小组的地理定位信息对条目进行位置辅助搜索和过滤。因此，ProGlycProt V2.0继续作为关于原核生物中蛋白质糖基化的各种基于证据的信息的有用的一点网络资源。
Knowledge of glycosylation status and glycan-pattern of proteins are of considerable medical, academic and application interest. ProGlycProt V2.0 (www.proglycprot.org) therefore, is conceived and maintained as an exclusive web-resource providing comprehensive information on experimentally validated glycoproteins and protein glycosyltransferases (GTs) of prokaryotic origin. The second release of ProGlycProt features a major update with a 191% increase in the total number of entries, manually collected and curated from 607 peer-reviewed publications, on the subject. Protein GTs from prokaryotes that catalyze a varied range of glycan linkages are amenable glycoengineering tools. Therefore, the second release presents content that is greatly expanded and reorganized in two sub-databases: ProGPdb and ProGTdb. While ProGPdb provides information about validated glycoproteins (222 entries), ProGTdb catalogs enzymes/proteins that are instrumental in protein glycosylation, directly (122) or as accessory proteins (182). ProGlycProt V2.0 remains highly cross-referenced yet exclusive and complementary in content to other related databases. The second release further features enhanced search capability, a “compare” entries option and an innovative geoanalytical tool (MapView) facilitating location-assisted search-cum filtering of the entries using geo-positioning information of researchers/groups cited in the ProGlycProt V2.0 databases. Thus, ProGlycProt V2.0 continues to serve as a useful one-point web-resource on various evidence-based information on protein glycosylation in prokaryotes.