The directed migration of eukaryotic cells.
The directed migration of eukaryotic cells.
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DOI：
10.1146/annurev.cb.02.110186.002005
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
S. Singer;A. Kupfer
中科院分区：
文献类型：
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作者：
S. Singer;A. Kupfer
真核细胞在表面上的体内迁移对于广泛的生理过程是重要的，例如胚胎发育、抵抗感染、伤口愈合、淋巴细胞归巢至淋巴器官和肿瘤转移（cf Trinkaus 1984）。尽管进行了大量的研究，细胞的定向迁移仍然没有得到很好的理解，毫无疑问，这是因为它确实是一个复杂的问题。复杂性的一部分是由于不同类型的运动细胞表达的运动表型的巨大变化。许多不同的细胞可以在适当的情况下迁移：在这篇文章中，我们指的是成纤维细胞，内皮细胞，上皮细胞，巨噬细胞，粒细胞，鱼表皮角质细胞和阿米巴的定向迁移。这些细胞类型中的许多显示出不同的运动特征。然而，大多数研究者认为，共同的机制必须在所有的细胞迁移。
The in vivo migration of eukaryotic cells over surfaces is important to a wide range of physiological processes, such as the development of the embryo, defense against infections, wound healing, the homing of lym phocytes to lymphoid organs, and tumor metastases (cf Trinkaus 1 984). Despite much study, the directed migration of cells is not yet well under stood, no doubt because it is indeed a complex problem. Part of the complexity is due to the great variety of locomotory phenotypes that are expressed by different types of motile cells. Many different cells can migrate under appropriate circumstances: In this article we refer to the directed migration of fibroblasts, endothelial cells, epithelial cells, macrophages, granulocytes, fish epidermal keratocytes, and amebae. Many of these cell types show distinct locomotory characteristics. However, most inves tigators agree that common mechanisms must operate in all cell migration.