Sleep variability in adolescence is associated with altered brain development.
Sleep variability in adolescence is associated with altered brain development.
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DOI：
10.1016/j.dcn.2015.05.007
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发表时间：
2015-08
影响因子：
4.7
通讯作者：
Gálvan A
中科院分区：
文献类型：
--
作者：
Telzer EH;Goldenberg D;Fuligni AJ;Lieberman MD;Gálvan A
每天的睡眠是在DTI扫描前1.5年零几个月测量的。青春期的睡眠变异性与低FA有关。青春期睡眠时间与FA无关。睡眠变化可能会对大脑发育产生持久的影响。尽管众所周知睡眠对大脑发育的重要性，而且青春期睡眠不佳的情况急剧增加，但我们对睡眠如何影响发育中的大脑知之甚少。我们提出了第一项纵向研究，以检验青春期睡眠与脑白质完整性之间的关系。我们发现，DTI扫描前一年睡眠时间的变化越大，除了睡眠时间和就寝时间的影响之外，脑白质完整性就越低，而扫描前几个月的睡眠变化与脑白质完整性无关。因此，青春期睡眠时间的变化可能会对发育中的大脑造成长期损害。在青春期，白质的完整性应该会增加，所以睡眠的可变性与正常的发育趋势直接相悖。
Daily sleep was measured 1.5 years and a few months prior to a DTI scan. Sleep variability in adolescence was associated with lower FA. Sleep duration in adolescence was not associated with FA. Sleep variability may have lasting impact on brain development. Despite the known importance of sleep for brain development, and the sharp increase in poor sleep during adolescence, we know relatively little about how sleep impacts the developing brain. We present the first longitudinal study to examine how sleep during adolescence is associated with white matter integrity. We find that greater variability in sleep duration one year prior to a DTI scan is associated with lower white matter integrity above and beyond the effects of sleep duration, and variability in bedtime, whereas sleep variability a few months prior to the scan is not associated with white matter integrity. Thus, variability in sleep duration during adolescence may have long-term impairments on the developing brain. White matter integrity should be increasing during adolescence, and so sleep variability is directly at odds with normative developmental trends.