Computational modeling of brainstem circuits controlling locomotor frequency and gait
Computational modeling of brainstem circuits controlling locomotor frequency and gait
复制标题
DOI：
10.7554/elife.43587
复制
发表时间：
2019-01-21
期刊：
影响因子：
7.7
通讯作者：
Rybak, Ilya A.
中科院分区：
文献类型：
--
作者：
Ausborn, Jessica;Shevtsova, Natalia A.;Rybak, Ilya A.
最近的一系列研究发现，小鼠中脑运动区和尾侧脑干的关键结构参与了慢速（探索性）和快速（逃跑型）运动和步态的启动和控制。然而，这些脑干中心彼此之间以及与脊髓运动回路之间的相互作用尚不清楚。之前我们提出，联合和长本体脊髓中间神经元是脑干输入调节步态的主要目标（Danner等，2017）。在这里，通过扩展我们之前的模型，我们提出了脑干-脊髓回路的连接组，并提出了脑干结构运作及其在控制速度和步态中的作用的机制解释。我们认为脑干对运动的控制是由两条途径介导的，一条途径通过连接脊髓中的节律产生回路来控制运动速度，另一条途径通过联合和长本体脊髓中间神经元来控制步态。
A series of recent studies identified key structures in the mesencephalic locomotor region and the caudal brainstem of mice involved in the initiation and control of slow (exploratory) and fast (escape-type) locomotion and gait. However, the interactions of these brainstem centers with each other and with the spinal locomotor circuits are poorly understood. Previously we suggested that commissural and long propriospinal interneurons are the main targets for brainstem inputs adjusting gait (Danner et al., 2017). Here, by extending our previous model, we propose a connectome of the brainstem-spinal circuitry and suggest a mechanistic explanation of the operation of brainstem structures and their roles in controlling speed and gait. We suggest that brainstem control of locomotion is mediated by two pathways, one controlling locomotor speed via connections to rhythm generating circuits in the spinal cord and the other providing gait control by targeting commissural and long propriospinal interneurons.